thalidomiden.
/θəˈlɪdəmʌɪd/, U.S. /θəˈlɪdəˌmaɪd/ A non-barbiturate sedative and hypnotic, C13H10N2O4, which was found to be teratogenic when taken early in pregnancy, sometimes causing malformation or absence of limbs in the fœtus.
ΘΚΠ
the world > health and disease > healing > medicines or physic > medicines for specific purpose > sedatives, antispasmodics, etc. > [noun] > sedative or hypnotic drugs
barbituric acid1866
adalin1911
allonal1921
Soneryl1923
barbiturate1928
sodium Amytal1929
allobarbitone1934
amylobarbitone sodium1945
Tuinal1949
amobarbital1950
quinalbarbitone1951
barb1955
ethchlorvynol1955
thalidomide1958
methaqualone1961
Quaalude1966
non-barbiturate1974
1958 Lancet 1 Feb. 271 The British Pharmacopœia Commission has issued the following new supplementary list of approved names:..Thalidomide..α-Phthalimido~glutarimide.
1961 Lancet 2 Dec. 1262/1 We have just received reports from two overseas sources possibly associating thalidomide (‘Distaval’) with harmful effects on the fœtus in early pregnancy.
1962 New Scientist 28 June 717/1 The tragic cost of the use of thalidomide.
1969 N. W. Pirie Food Resources vii. 167 Thalidomide is the classic example of a substance that passed orthodox tests that were, as it turned out, not relevant.
1978 Dædalus Spring 136 Passage of the 1962 drug law might not have occurred without the public demand for stricter controls over the testing of new drugs following disclosure of deformities caused by Thalidomide.
1979 Nature 29 Nov. 509/1 Other agents, notably Thalidomide, are believed to be teratogenic by virtue of metabolic products rather than the parent compound.
Compounds
C1. attributive and in other combinations.
ΚΠ
1962 Lancet 1 Dec. 1155/2 Attempts have been made to lengthen stunted thalidomide arms by grafts from fibula and scapula.
1973 Daily Tel. 9 Jan. 2/2 A Pharmaceutical Society spokesman said..that the scale of the thalidomide compensation would undoubtedly have a ‘profound effect’ on the manufacture of new drugs in Britain.
1977 J. D. Douglas in J. D. Douglas & J. M. Johnson Existential Sociol. i. 26 Her highly publicized abortion in Sweden for a thalidomide-damaged fetus.
1980 Nature 1 May 54/1 The thalidomide tragedy, for example, could have been averted if this synthetic racemate had been separated into its optical isomers, for only the left-handed (s)-(−)-isomer has teratogenic properties.
1981 Daily Tel. 3 Feb. 2/2 This is the first known case of a thalidomide victim becoming a father, although a couple of incidences of thalidomide mothers are known.
C2.
thalidomide baby n. = thalidomide child n.
ΘΚΠ
the world > health and disease > ill health > deformity > [noun] > abnormally-formed fetus
monstera1400
scarth?a1513
mooncalfa1616
pretergeneration1640
misbirth1648
terata1902
embryopathy1917
thalidomide baby1962
thalidomide child1971
1962 Guardian 31 July 14/2 There is still no information about the number of ‘thalidomide babies’ in the country.
thalidomide child n. one born deformed through the effects of thalidomide.
ΘΚΠ
the world > health and disease > ill health > deformity > [noun] > abnormally-formed fetus
monstera1400
scarth?a1513
mooncalfa1616
pretergeneration1640
misbirth1648
terata1902
embryopathy1917
thalidomide baby1962
thalidomide child1971
1971 New Scientist 18 Mar. 613/1 The construction of a body harness for armless thalidomide children.
1979 T. Benn Arguments for Socialism ii. 49 There was also the initial refusal by Distillers to compensate the thalidomide children properly.
This entry has not yet been fully updated (first published 1986; most recently modified version published online March 2022).
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n.1958