| 释义 |
progeria Path.|prəʊˈdʒɪərɪə|
[mod.L., f. Gr. προγήρ-ως prematurely old + -ia1.]
A fatal disease of children characterized by symptoms usually associated with senility.
1904H. Gilford in Practitioner Aug. 210 The name progeria, for which I am indebted to Mr. James Rhoades and Professor Arthur Sidgwick, is not only a far better word [than micromegaly], but is a true description of the distinguishing features of the two cases. Ibid. 217 The name progeria..has been given in recognition of the senile characters which form such a conspicuous feature of the disease from the beginning. 1927Times (Weekly ed.) 28 Apr. 475/2 Cases of premature senility in children (goblins) described as progeria, the persistence in an adult (ateleioses) of child characters (elves). 1957L. Eiseley Immense Journey 108 The cause of this curious disease, known as progeria, or premature aging, is totally unknown. 1969Guardian 13 Jan. 2/3 A post-mortem examination will be carried out on..a 9-year-old girl who died of a disease that gave her the physical characteristics of a 90-year-old woman. Norma..was the second member of her family to be suffering from progeria.
Hence † proˈgerian n., a person with progeria; also attrib.; proˈgeric a., of or being a person with progeria.
1913Lancet 1 Feb. 305/1 Progerians pass from a delayed childhood into a premature old age. Ibid. 306/1 The total length of the progerian face from nasion to chin is only 84 mm. 1914Boston Med. & Surg. Jrnl. 16 July 110/2 Progerians are usually dwarfs. 1933R. W. B. Ellis tr. Apert's Infantilism vii. 73 (caption) Mould of the upper and lower jaws in the same progeric patient as in figs. 11 and 12. 1945Amer. Jrnl. Dis. Children LXIX. 276/2 The conditions..are postulated for the progeric patient..during the period from 2 to 6 years of age, when most of his subcutaneous fat vanished. 1976Nature 22 Apr. 713/1 With factor VII-deficient plasma, both normal and progeric cells showed a markedly prolonged clotting time. |