| 释义 |
osteoid, a. and n.|ˈɒstɪɔɪd|
[f. osteo- + -oid: cf. Gr. ὀστοειδής and ὀστεώδης bone-like, bony.]
A. adj. Resembling bone; of the appearance or structure of bone; bony, osseous; spec. consisting of or being the uncalcified amorphous matrix that is the organic constituent of bone.
osteoid osteoma, a characteristic kind of benign tumour of bone, small and usu. painful.
1840C. West tr. Müller's Nature of Cancer I. ii. i. 136 The osteoid tumor of the bones..is a growth composed entirely of osseous substance. 1859Proc. R. Soc. IX. 662 It seems to follow that the peculiar distribution of real osseous tissue and of the ‘osteoid’ structure, as the osseous tissue without [bone-]corpuscles may be called, has a deeper signification. 1859S. Wilks Lect. Path. Anat. i. 31 There is encephaloid and scirrhous cancer of bone,..if the latter is wholly ossified, we have osteoid cancer. 1870Rolleston Anim. Life 46 In their bony or osteoid tissue fish resemble the Amphibia. 1875Wilks & Moxon Lect. Path. Anat. (ed. 2) 54 The microscope shows a structure which can best be compared to those plates of osteoid cartilage which are so common on the spinal pia mater after middle life, i.e. it closely resembles bone which has been decalcified by acids. 1899Allbutt's Syst. Med. VI. 9 Normally in molluscs, osteoid fish, and reptiles, only two cusps form. 1916E. H. Kettle Path. Tumours ii. 96 A tumour may form osteoid tissue consisting of trabeculæ, almost typical in every respect except that there is no deposition of calcium salts in the matrix. 1935H. L. Jaffe in Arch. Surg. XXXI. 724 One feels forced to conclude that one is dealing here with a benign bone neoplasm the distinctiveness of which has not hitherto been recognized and which I am designating ‘osteoid-osteoma’. 1950A. W. Ham Histol. xvi. 190/2 Under normal conditions..newly formed bone exists in an uncalcified or osteoid state for only a transitory period. 1966Wright & Symmers Systemic Path. I. xxxvii. 1400 An osteoid osteoma takes the form of a rounded mass of gritty, reddish-grey tissue... Histologically.., the lesion consists of vascular osteoblastic tissue, containing much osteoid matrix and some calcified bone. 1969W. A. Beresford Lect. Notes Histol. vii. 49 The osteoid seam is a very poorly mineralized zone of matrix, 1–3 µ wide, seen with light microscopy between the true bone and the active osteoblasts.
B. n.
†a. A kind of malignant tumour composed of osteoid tissue. [The original sense, after G. osteoid n. (J. Müller Ueber den feinern Bau und die Formen der krankhaften Geschwülste (1838) 44).] Obs.
1847–9R. B. Todd Cycl. Anat. & Physiol. IV. i. 135/2 Osteoid.—Under the names of osteoid or ossifying fungous tumour, Müller describes a growth..composed of a greyish white, vascular, nodulated substance, of the consistence of fibro-cartilage. 1854W. E. Swaine tr. Rokitansky's Man. Path. Anat. I. ix. 181 This series [of new-growths]..separates into the osteoid, and into the bony concretion. Ibid. 185 Müller's osteoid is a bone-formation which enters redundantly into the parenchyma of cancer.
b. Osteoid tissue, uncalcified bone. Also attrib.
1934Vet. Jrnl. XC. 157 They were not considered to be genuinely rachitic, because the pathognomic osteoid formation was absent, or the amount of osteoid was not considered sufficient. 1943Bull. Johns Hopkins Hosp. LXXII. 236 Osteoid in the normal adult individual is usually absent or very scanty. 1963Jubb & Kennedy Path. Domestic Animals I. i. 9/2 Osteoid consists of fibrillar protein (collagen) in a non-fibrillar medium which is probably largely of mucopolysaccharides. 1972H. L. Jaffe Metabolic Dis. Bones xv. 387 It is the presence of abundant osteoid that characterizes the histologic picture of both rickets and osteomalacia. 1972Science 2 June 1032/3 Light microscopic observations indicated no obvious differences between treated and control cultures with respect to proliferation of boneforming cells or degree of osteoid formation. |