| 释义 |
osteodystrophy Med.|ɒstiːəʊˈdɪstrəfɪ|
Also as mod.L. -dystrophia.
[f. (in Ger.) as mod.L. osteodystrophia (J. von Mikulicz 1905, in Verhandl. d. Ges. deutsch. Naturforscher und Ärzte LXXVI. ii. Med. Abt. 108), f. osteo- + dystrophia s.v. dys-: see -y3.]
Any of several disorders affecting the whole skeleton in which there is defective bone development owing to a badly balanced diet or faulty metabolism; spec. one in which there is increased resorption of bone and its replacement by fibrous and poorly mineralized tissue, producing skeletal pain and brittle bones, which are often enlarged and deformed in the young; it occurs in animals, esp. horses, as a result of too high a ratio of dietary phosphorus to calcium (osteodystrophia fibrosa [coined in Ger. by T. Stenholm in Pathologisch-anat. Studien über die Osteodystrophia Fibrosa (1924) 90]), and in man in association with chronic renal insufficiency and hyperparathyroidism (renal osteodystrophy).
1930Jrnl. Exper. Med. LII. 669 (heading) Experimental fibrous osteodystrophy (ostitis fibrosa) in hyperparathyroid dogs. Ibid. 690 The hypostotic-porotic form of osteo⁓dystrophia fibrosa. 1932W. Boyd Text-bk. Path. xxxi. 883 Among these..osteitis fibrosa, osteitis deformans, osteomalacia, rickets,..hereditary chondrodysplasia, and marble bones may be mentioned. As they are disorders of the growth of bone they may be considered together under the heading of the osteodystrophies. 1953Jrnl. Path. & Bacteriol. LXV. 302 In severe renal osteodystrophy the local upheaval in bone formation may result in the development of lesions resembling either osteopetrosis or Paget's disease. 1963Jubb & Kennedy Path. Domestic Animals I. i. 8/1 The classical osteodystrophies are rickets, osteomalacia, and osteodystrophia fibrosa. Ibid. 25/1 (heading) The osteodystrophy of fluorine poisoning. 1966Wright & Symmers Systemic Path. II. xxxvii. 1384/2 Renal osteodystrophy is..one of the commonest metabolic diseases of bone. The bone changes consist of fibrous replacement of bone..together with rickets or osteomalacia. 1970A. R. Jennings Animal Path. xii. 233 Equine osteodystrophia fibrosa arises if horses are fed on a diet containing large quantities of bran which is rich in phosphorus. The same situation is sometimes seen in pigs... In dogs, however, the prime cause is renal insufficiency with secondary hyperparathyroidism. 1974Passmore & Robson Compan. Med. Stud. III. i. xxii. 10/2 The clinical features of renal osteodystrophy are most marked in children, in whom there is growth retardation.
So ˌosteodyˈstrophic a.
1925Physiol. Abstr. IX. 529 Osteodystrophic factors in different animals. 1960Proc. Zool. Soc. CXXXIV. 307 Osteo-dystrophic conditions have been recognized in New World monkeys for many years. |