cannabinoidn.
/ˈkanəbɪnɔɪd/, U.S. /ˈkænəbᵻˌnɔɪd/ Chemistry.
Any of a group of substances including cannabinol, cannabidiol, and other structurally related compounds of natural and synthetic origin. In later use also (in full endogenous cannabinoid): any of a group of compounds, typically derivatives of arachidonic acid, which occur naturally in animals and are able to bind to the same cellular receptors as those which bind plant cannabinoids.
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the world > matter > chemistry > organic chemistry > organic compounds > [noun] > cyclic compounds > tricyclic compounds
xanthene1898
thioxanthene1911
psoralen1933
lysergic acid1934
cannabinoid1967
1967 R. Mechoulam & Y. Gaoni in Fortschritte der Chemie Organischer Naturstoffe 25 178 We propose the term cannabinoids for the group of C21-compounds typical of and present in C. sativa, as well as for their analogs and transformation products.
1974 M. C. Gerald Pharmacol. xviii. 339 Cannabis contains a group of closely related compounds that are collectively termed cannabinoids... These compounds do not contain a nitrogen atom and, therefore, are not alkaloids.
2000 J. Mann Murder, Magic, & Med. (rev. ed.) iii. 85 Raphael Mechoulam isolated the substance anandamide in 1992 from pig brain, and showed that this substance bound to the cannabinoid receptor. It was thus an endogenous mammalian cannabinoid.
2010 Wall St. Jrnl. 17 July a14/4 Spice, a synthetic cannabinoid that is similar to cannabis, became popular in Europe in 2008 and was subsequently banned.
Compounds
C1. General attributive.
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1967 R. Mechoulam & Y. Gaoni in Fortschritte der Chemie Organischer Naturstoffe 25 197 (heading) Chemical transformations in the cannabinoid series.
1976 R. E. Willette Cannabinoid Assays in Humans (National Inst. Drug Abuse Res. Monograph No. 7) p. v We can begin to establish specific correlations between cannabinoid levels and driving impairment.
1987 Bot. Gaz. 148 473/2 Cannabinoid acids may be unstable after extraction and are readily converted to their neutral forms on heating or storage.
2003 C. Berlinski Loose Lips i. 15 I admitted..that I'd had some acquaintance with the cannabinoid family, as they called it, but I left ambiguous the issue of quantity.
2012 Proc. National Acad. Sci. U.S.A. 109 12811/2 Cannabinoid biosynthesis occurs primarily in glandular trichomes that develop on female flowers and, to a lesser extent, leaves.
C2.
cannabinoid receptor n. Physiology any of a class of cellular receptors that bind cannabinoids and which are found in the central nervous system and various other tissues.
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1976 W. D. M. Paton in G. G. Nahas Marihuana: Chem., Biochem., & Cellular Effects 552 Many of these studies in cell biology are taking us toward an understanding of the possible mechanisms of action of THC. Should one think of a cannabinoid receptor?
1987 Neuropharmacol. 26 507/1 The response to cannabinoids may be the result of stimulation of a ‘cannabinoid’ receptor.
2004 D. Benton in A. Nehlig Coffee, Tea, Chocolate, & Brain xv. 213 Anandamide is a brain lipid that binds to cannabinoid receptors.
This entry has been updated (OED Third Edition, March 2019; most recently modified version published online December 2021).
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n.1967