to the sense: to a point of extreme or unbearable pain or sensitivity. Cf. to the quick at quick, n.1 3a. Obsolete. rare.

In an irritating or annoying manner; so as to provoke irritation; exasperatingly; to a provoking degree.

In an aggravating manner; in a manner that makes worse or more serious, exasperates, etc.

in an exasperating manner; provokingly.

in an irritating way.

In a nagging or insistent way; in a persistently irritating, annoying, complaining, or exhausting manner.