To burden with care, burden as care does; to worry, harass, vex, trouble. (Mostly in past participle) Obsolete or archaic; but see carking, adj.

transitive. To afflict with mental agitation or trouble; to make anxious or depressed; to distress deeply or seriously; to torment with worry or…

To disturb, disquiet, trouble; to make anxious, fill with concern. Obsolete.

transitive. To render busy, occupy assiduously; to give care or anxiety to. Chiefly reflexive.

figurative. to lie at one's heart: to be the object of one's affection or desire. Similarly, to lie heavy ator to one's heart: to give one grave…

transitive. slang (chiefly U.S.). to weird out: to induce a sense of discomfort, alienation, strangeness, etc., in; to make anxiously…

transitive. To cause (a person) stress or anxiety. Cf. stressed out adj. at stressed, adj. n.compounds.