tyrosinosisn.
/tʌɪrəsɪˈnəʊsɪs/ Medicine.
A rare condition of unknown ætiology in which there is increased excretion of the early metabolites of tyrosine but no liver or kidney damage; also (now rare) = tyrosinaemia n.
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the world > health and disease > ill health > a disease > disorders of internal organs > metabolic disorders > [noun] > other metabolic disorders
xanthomatosis1900
Tay-Sachs1907
ketosis1917
protein shock1917
hyperinsulinism1924
Niemann–Pick1928
tyrosinosis1932
von Gierke's disease1933
phenylketonuria1935
cystic fibrosis1938
mucoviscidosis1945
cystinosis1949
oxalosis1952
McArdle1957
orotic aciduria1959
PKU1961
sphingolipidosis1962
Reye's syndrome1965
Menkes1969
1932 G. Medes in Biochem. Jrnl. XXVI. 938 The essential feature in our patient..consists in a complete stoppage of the oxidation of tyrosine at the stage of p-hydroxyphenylpyruvic acid... Thus results an excretion not only of p-hydroxyphenylpyruvic acid and..l-p-hydroxyphenyllactic acid, but also of tyrosine and..l-3:4-dihydroxyphenylalanine. For this condition, the name tyrosinosis is proposed.
1942 Jrnl. Physiol. 101 345 In tyrosinosis l(−)-dopa was found to be excreted in the urine after oral administration of l(−)-tyrosine.
1969 New Scientist 3 July 10/1 Prevention of postnatal brain damage by dietary treatment has been reported in a number of other inborn errors of metabolism. Examples include galactosaemia, tyrosinosis, maple syrup urine disease and possibly homocystinuria.
1974 R. Passmore & J. S. Robson Compan. Med. Stud. III. xlvii. 8/1 Formerly hypertyrosinaemia or tyrosinosis was considered to be a single, exceedingly rare abnormality.
1982 T. I. Diamondstone in T. M. Devlin Textbk. Biochem. xii. 589/1 Tyrosinosis and the tyrosinemias have certain biochemical features in common.
This entry has not yet been fully updated (first published 1986; most recently modified version published online June 2018).
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n.1932