monobactamn.

Brit.

/ˌmɒnə(ʊ)ˈbaktəm/, U.S.

/ˌmɑnəˈbækt(ə)m/

Origin: Formed within English, by compounding. Etymons: monocyclic adj., beta n., lactam n.

Etymology: < mono- (in monocyclic adj.) + -b- (in beta n.) + -actam (in lactam n.): see quot. 1981.

Pharmacology.

Any of a class of monocyclic antibiotics that consist of a single β-lactam ring with an amino- or amide-containing side chain, originally isolated from bacteria and now also manufactured synthetically.

ΚΠ

1981 R. B. Sykes et al. in Nature 11 June 489/2 We have now identified seven related molecules containing β-lactams produced by a range of bacterial species. For this new family of monocyclic β-lactams we suggest the class name ‘monobactam’.

1988 Q. N. Myrvik & R. S. Weiser Fund. Med. Bacteriol. & Mycol. (ed. 2) vi. 95 Monobactams..bind to PBP-3 in the bacterial cell wall, producing changes that ultimately destroy the organism.

1997 Burns 23 225 We evaluated the role of the monobactam aztreonam in burn wound infections and compared it to the aminoglycosides amikacin and gentamicin.

This is a new entry (OED Third Edition, December 2002; most recently modified version published online March 2022).

单词	monobactam
释义	monobactamn. Brit. /ˌmɒnə(ʊ)ˈbaktəm/, U.S. /ˌmɑnəˈbækt(ə)m/ Origin: Formed within English, by compounding. Etymons: monocyclic adj., beta n., lactam n. Etymology: < mono- (in monocyclic adj.) + -b- (in beta n.) + -actam (in lactam n.): see quot. 1981. Pharmacology. Any of a class of monocyclic antibiotics that consist of a single β-lactam ring with an amino- or amide-containing side chain, originally isolated from bacteria and now also manufactured synthetically. ΚΠ 1981 R. B. Sykes et al. in Nature 11 June 489/2 We have now identified seven related molecules containing β-lactams produced by a range of bacterial species. For this new family of monocyclic β-lactams we suggest the class name ‘monobactam’. 1988 Q. N. Myrvik & R. S. Weiser Fund. Med. Bacteriol. & Mycol. (ed. 2) vi. 95 Monobactams..bind to PBP-3 in the bacterial cell wall, producing changes that ultimately destroy the organism. 1997 Burns 23 225 We evaluated the role of the monobactam aztreonam in burn wound infections and compared it to the aminoglycosides amikacin and gentamicin. This is a new entry (OED Third Edition, December 2002; most recently modified version published online March 2022). < n.1981
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