intransitive. Of a person: to fail in one's purpose or object; to be unsuccessful. †Also with of.

Badly, without success. Only in to come off bluely and variants. Now archaic and rare.

slang. to buy the rabbit: to get the worst of a deal, to fare badly. Now rare.

intransitive. To give up, back out, fail utterly. Also to flunk out. Also quasi-transitive. To shirk (a recitation) (Standard Dict.).

to go wrong. Of persons: To fail in some undertaking or enterprise, or in the general conduct of life.

With up. To defraud or swindle; to disappoint. Australian slang.

to fall (also go) by the wayside: to fail to stay the course, to drop out; to become superseded or neglected.

figurative. To come to pieces, collapse, break down. (Cf. the bank broke.) Also frequently with up. Cf. crack-up, n.

In specific applications usually indicated by context. down the tube(s), lost, finished, in trouble; frequently in to go down the tube(s) = to go down…