acridine orange

ac·ri·dine or·ange

(ak'ri-dēn ōr'enj), [C.I. 46005] 3,6-bis(dimethylamino)acridine hydrochloride; a basic fluorescent dye useful as a metachromatic stain for nucleic acids; also used in screening cervical smears for abnormal and malignant cells, where unusual amounts of DNA and RNA occur during proliferation and in tumors (DNA fluoresces yellow to green; RNA fluoresces orange to red). Synonym(s): tetramethyl acridine

An immunologic fluorochrome—fluorescent dye—that nonspecifically binds to RNA (red fluorescence), DNA (green fluorescence), proteins, polysaccharides, glycosaminoglycans
Toxicology AO is carcinogenic, causing mutations by intercalating itself within replicating DNA causing insertional or deletional (‘frame shift’) mutations; AO is not routinely used in histologic laboratories

ac·ri·dine or·ange

(ak'ri-dēn awr'ănj) [CI 46005] A basic fluorescent dye useful as a metachromatic stain for nucleic acids; also used in screening cervical smears for abnormal and malignant cells.

单词	acridine orange
释义	acridine orange acridine orange [′ak·rə‚dēn ′är·inj] (organic chemistry) A dye with an affinity for nucleic acids; the complexes of nucleic acid and dye fluoresce orange with RNA and green with DNA when observed in the fluorescence microscope. acridine orange ac·ri·dine or·ange (ak'ri-dēn ōr'enj), [C.I. 46005] 3,6-bis(dimethylamino)acridine hydrochloride; a basic fluorescent dye useful as a metachromatic stain for nucleic acids; also used in screening cervical smears for abnormal and malignant cells, where unusual amounts of DNA and RNA occur during proliferation and in tumors (DNA fluoresces yellow to green; RNA fluoresces orange to red). Synonym(s): tetramethyl acridine An immunologic fluorochrome—fluorescent dye—that nonspecifically binds to RNA (red fluorescence), DNA (green fluorescence), proteins, polysaccharides, glycosaminoglycans Toxicology AO is carcinogenic, causing mutations by intercalating itself within replicating DNA causing insertional or deletional (‘frame shift’) mutations; AO is not routinely used in histologic laboratories ac·ri·dine or·ange (ak'ri-dēn awr'ănj) [CI 46005] A basic fluorescent dye useful as a metachromatic stain for nucleic acids; also used in screening cervical smears for abnormal and malignant cells. AcronymsSeeall out
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