t-plasminogen activator


t-plasminogen activator

 [plaz-min´o-jen ak´tĭ-va″tor] see tissue plasminogen activator.

PLAT

A gene on chromosome 8p12 that encodes tissue plasminogen activator, which converts inactive plasminogen to plasmin by hydrolysing a single Arg-Val bond in plasminogen, thereby playing a key role in tissue remodelling, degradation, cell migration and other cellular events. PLAT directly facilitates neuronal migration.