microsatellite instability


microsatellite instability

An abnormality in a DNA sequence in which a microsatellite (repeating 2–6 nucleotides) found in intronic DNA is either longer or shorter than normal, which is most commonly due to defective mismatch repair.

microsatellite instability

A detectable change in the number of DNA repeat sequences that may lead to mutations in mismatch-repair genes.