AIDS cholangiopathy

AIDS cholangiopathy

A bile obstruction syndrome caused by infection-related strictures of the biliary tract, which occurred in up to 25% of patients in the pre-HAART (highly active antiretroviral therapy) era; it is more common in those with CD4 counts of < 100/mm3.
Clinical findings
Chronic right upper quadrant and epigastric pain, low-grade fever, diarrhoea, cholestasis with bile duct ectasia, bile duct defects, papillary stenosis.
 
Aetiology
Cryptosporidium parvum, CMV, Microsporidium, Enterocytozoon bieneusi, Encephalitozoon intestinalis, Mycobacteriium tuberculosis.