transdifferentiationn.

Brit.

/ˌtranzdɪfərɛnʃɪˈeɪʃn/,

/ˌtrɑːnzdɪfərɛnʃɪˈeɪʃn/,

/ˌtransdɪfərɛnʃɪˈeɪʃn/,

/ˌtrɑːnsdɪfərɛnʃɪˈeɪʃn/, U.S.

/ˈˌtrænzdɪfəˌrɛn(t)ʃiˈeɪʃ(ə)n/,

/ˈˌtræn(t)sdɪfəˌrɛn(t)ʃiˈeɪʃ(ə)n/

Origin: Formed within English, by derivation. Etymons: trans- prefix, differentiation n.

Etymology: < trans- prefix + differentiation n. Compare transdifferentiate v.Compare the following isolated earlier example in a slightly different sense, translating German Umdifferenzierung:1968 Histochemie 16 119 (heading) Changing adenosine triphosphatase activity in nucleus of cultured chicken heart myoblasts during their transdifferentiation.

Biology.

The change of one type of differentiated or developmentally committed cell into another type; metaplasia.

ΚΠ

1971 F. C. Kafatos in Endocrinologia Experimentalis 5 101 But what we might call transdifferentiation, the transformation of a cell to a different, equally specialised type, has been difficult to establish with certainty.

1974 Tissue & Cell 6 746/1 Labial gland transdifferentiation analogous to that in saturniids also occurs in Manduca.

1993 N.Y. Times 31 Aug. c3/4 The Wilm's tumor gene has a broad role in this crucial transdifferentiation event.

2003 Science 9 May 865 Adult stem cells..can produce tissues of their own type, and possibly others by a process that developmental biologists call ‘transdifferentiation’.

This is a new entry (OED Third Edition, June 2007; most recently modified version published online March 2022).

单词	transdifferentiation
释义	transdifferentiationn. Brit. /ˌtranzdɪfərɛnʃɪˈeɪʃn/, /ˌtrɑːnzdɪfərɛnʃɪˈeɪʃn/, /ˌtransdɪfərɛnʃɪˈeɪʃn/, /ˌtrɑːnsdɪfərɛnʃɪˈeɪʃn/, U.S. /ˈˌtrænzdɪfəˌrɛn(t)ʃiˈeɪʃ(ə)n/, /ˈˌtræn(t)sdɪfəˌrɛn(t)ʃiˈeɪʃ(ə)n/ Origin: Formed within English, by derivation. Etymons: trans- prefix, differentiation n. Etymology: < trans- prefix + differentiation n. Compare transdifferentiate v.Compare the following isolated earlier example in a slightly different sense, translating German Umdifferenzierung:1968 Histochemie 16 119 (heading) Changing adenosine triphosphatase activity in nucleus of cultured chicken heart myoblasts during their transdifferentiation. Biology. The change of one type of differentiated or developmentally committed cell into another type; metaplasia. ΚΠ 1971 F. C. Kafatos in Endocrinologia Experimentalis 5 101 But what we might call transdifferentiation, the transformation of a cell to a different, equally specialised type, has been difficult to establish with certainty. 1974 Tissue & Cell 6 746/1 Labial gland transdifferentiation analogous to that in saturniids also occurs in Manduca. 1993 N.Y. Times 31 Aug. c3/4 The Wilm's tumor gene has a broad role in this crucial transdifferentiation event. 2003 Science 9 May 865 Adult stem cells..can produce tissues of their own type, and possibly others by a process that developmental biologists call ‘transdifferentiation’. This is a new entry (OED Third Edition, June 2007; most recently modified version published online March 2022). < n.1971
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