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单词 thrombase
释义

thrombasen.

Brit. /ˈθrɒmbeɪz/, U.S. /ˈθrɑmˌbeɪs/, /ˈθrɑmˌbeɪz/
Origin: Formed within English, by derivation; modelled on a French lexical item. Etymons: thrombo- comb. form, -ase suffix.
Etymology: < thrombo- comb. form + -ase suffix, after French thrombase (1898 or earlier). Compare slightly earlier thrombin n.
Biochemistry. Now rare.
An enzyme that converts fibrinogen to fibrin; = thrombin n.Later used mainly in the context of the analysis of snake venoms, apparently denoting any substance which promotes intravascular coagulation.
ΚΠ
1899 J. R. Green Soluble Ferments & Fermentation xvi. 250 We have seen that the fibrin ferment, which has recently been named thrombase, or thrombin, was originally prepared by Alexander Schmidt from defibrinated blood or from the serum which separates out from a normal clot.
1908 W. M. Bayliss Nature Enzyme Action 73 According to Morawitz there exists in circulating blood a body ‘thrombogen’, which can be converted by a ‘thrombokinase’ present in all tissues into a precursor of the enzyme which acts upon fibrinogen to form fibrin. This precursor, or prothrombase, is changed into the active thrombase by calcium ions.
1930 Proc. Royal Soc. B. 107 271 In this paper the preparation of prothrombase from oxalated mammalian blood is described and the conditions under which it is converted into thrombase—the enzyme which converts fibrinogen into thrombin—are considered.
1944 R. W. Nauss Med. Parasitol. & Zool. xvii. 365 Typical viper venom is characterized by the presence of hemorrhagin, thrombase, and cytolysins.
1989 R. T. Hoser Austral. Reptiles & Frogs i. 20/2 Other components of snake venom include:..thrombase, which causes blood clotting within vessels.
This entry has been updated (OED Third Edition, March 2017; most recently modified version published online March 2022).
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n.1899
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