sildenafiln.

Brit.

/sɪlˈdɛnəfɪl/, U.S.

/ˌsɪlˈdɛnəfᵻl/

Origin: Of unknown origin.

Etymology: Origin unknown.

Pharmacology.

A piperazine derivative that acts as a selective inhibitor of cyclic nucleotide (guanosine monophosphate) phosphodiesterase, and is given orally as the citrate (more fully sildenafil citrate) to improve blood flow into the penis and enhance erectile function; 1-[[3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulfonyl]-4-methyl-piperazine, C₂₂H₃₀N₆O₄S.A proprietary name for this drug is Viagra n.

ΚΠ

1995 PR Newswire (Nexis) 23 Oct. Sildenafil, for male erectile dysfunction (MED), showed a response rate as high as 90 percent in a large clinical trial of patients with a primarily psychologically based condition.

1996 Brit. Jrnl. Urol. 78 257 Sildenafil, a novel orally active inhibitor of the type-V cyclic guanosine monophosphate-specific phosphodiesterase (the predominant isoenzyme in the human corpus cavernosum).

1999 Irish Med. Jrnl. (Electronic ed.) 92 5 Sildenafil is absolutely contra-indicated in patients taking nitrates, whether continuous or episodic because of the severe hypotension that may result.

This is a new entry (OED Third Edition, September 2001; most recently modified version published online March 2022).

单词	sildenafil
释义	sildenafiln. Brit. /sɪlˈdɛnəfɪl/, U.S. /ˌsɪlˈdɛnəfᵻl/ Origin: Of unknown origin. Etymology: Origin unknown. Pharmacology. A piperazine derivative that acts as a selective inhibitor of cyclic nucleotide (guanosine monophosphate) phosphodiesterase, and is given orally as the citrate (more fully sildenafil citrate) to improve blood flow into the penis and enhance erectile function; 1-[[3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulfonyl]-4-methyl-piperazine, C₂₂H₃₀N₆O₄S.A proprietary name for this drug is Viagra n. ΚΠ 1995 PR Newswire (Nexis) 23 Oct. Sildenafil, for male erectile dysfunction (MED), showed a response rate as high as 90 percent in a large clinical trial of patients with a primarily psychologically based condition. 1996 Brit. Jrnl. Urol. 78 257 Sildenafil, a novel orally active inhibitor of the type-V cyclic guanosine monophosphate-specific phosphodiesterase (the predominant isoenzyme in the human corpus cavernosum). 1999 Irish Med. Jrnl. (Electronic ed.) 92 5 Sildenafil is absolutely contra-indicated in patients taking nitrates, whether continuous or episodic because of the severe hypotension that may result. This is a new entry (OED Third Edition, September 2001; most recently modified version published online March 2022). < n.1995
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