redifferentiatev.
/ˌriːdɪfəˈrɛnʃɪeɪt/, U.S. /ˌridɪfəˈrɛn(t)ʃiˌeɪt/ 1. Biology.
a. transitive. To cause (cells or tissue) to become specialized again following loss of differentiation. Usually in passive.
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1867 H. Spencer First Princ. (ed. 2) ii. xv. 335 Meanwhile each of these differentiated tissues is re-differentiated.
1919 Biol. Bull. 36 312 One author..has gone so far as to claim that specialized cells (muscle) may even be de- and redifferentiated to form germ cells.
1992 Proc. National Acad. Sci. U.S.A. 89 4583 Chondrocytes..were dedifferentiated and expanded in monolayer culture and then redifferentiated by culture over agarose.
2006 Tissue Engin. 12 2435 After expansion, cells were either redifferentiated in pellet culture or seeded on collagen type II-coated filters.
b. intransitive. Esp. of cells or tissue: to become specialized again following a loss of differentiation; to undergo redifferentiation.
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1901 Science 5 July 29/1 The band of transparent tissue redifferentiates and the energy of growth is transferred to the regenerating region.
1911 Cornhill Mag. Apr. 497 This is no longer a man, but merely a mass of man's protoplasm,..as if finally this mass were to redifferentiate up again.
1960 E. N. Willmer in Symp. Soc. Exper. Biol. 14 30 Such a cell..would probably..creep with others as a flattened sheet over the underlying connective tissue or granulation tissue before beginning to redifferentiate.
2004 I. L. Slesnick Clones, Cats, & Chemicals 3 A team of graduate students took tiny fragments from a fully differentiated root of a carrot and forced it to dedifferentiate into embryonic cells..and then redifferentiate into a fully adult carrot plant.
2. intransitive and transitive. Mathematics. To differentiate (a function) that is itself a derivative; to differentiate again or further.
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1890 Cent. Dict. Redifferentiate v.i., to differentiate a differential or differential coefficient.
1906 A. Cohen Elem. Treat. Differential Equations ii. 84 Redifferentiating with respect to all the variables, and comparing with the given equation, [etc.].
1906 A. Cohen Elem. Treat. Differential Equations ii. 11 The rule is found to work so often that it seems worth mentioning, with the understanding..that when it is employed, the results be redifferentiated.
1954 Math. Gaz. 38 8 We laboriously integrate differential equations twice with regard to the time t, to give coordinates as functions of t, then re-differentiate these to give velocities.
1981 Q. Jrnl. Math. 32 8 In fact, if we differentiate ϕ′(s), multiply up the radical and redifferentiate we obtain a rational function of degree 5.
3. gen.
a. intransitive. To become further differentiated or specialized. Cf. differentiate v. 3b. rare.
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1896 F. H. Giddings Princ. Sociol. iii. iv. 331 The social constitution differentiates and redifferentiates, until it becomes a structure of exceeding complexity.
b. transitive. To differentiate (something) again or further.
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the world > relative properties > relationship > difference > differ from [verb (transitive)] > distinguish or differentiate
to-skillc1175
disguise1340
asunderc1425
differc1450
difference1490
sort1553
distinguish1576
particularize?1593
diversify1594
subdistinguish1610
discriminate1615
severalize1645
specify1645
disresemble1651
estrange1727
discrepate1828
differentialize1833
differentiate1838
dissimilate1876
redifferentiate1970
1970 Jrnl. Gen. Psychol. 82 182 He must again re-differentiate these boundaries.
1973 Diacritics 3 35/1 Literary structuralism..is quite literally mythical in the sense that it redifferentiates once more, just as mythology does, what the tragic writer takes such pains to undifferentiate.
1987 Ann. Rev. Sociol. 13 141 In our time, capital expansion has no new territory left to explore, so it redevelops, or internally redifferentiates, urban space.
1999 Theory & Soc. 28 50 By 1989, with the dismantling of the Second World, the postwar geopolitical division of the globe had been thoroughly redifferentiated, fragmented, and rearranged.
Derivatives
ˌrediffeˈrentiated adj. chiefly Biology (esp. of cells or tissue) having undergone redifferentiation.
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1971 Jrnl. Theoret. Biol. 30 165 In the absence of specific external influences capable of restoring the original metabolic state, the cell would remain in the ‘redifferentiated’, malignant form.
2000 A. Bass Difference & Disavowal iii. 112 ‘Narcissistic’ internalization of a redifferentiated analyst-patient relation.
2005 Jrnl. Biotechnol. 121 487/1 The redifferentiated chondrocytes are then recovered from the alginate gel.
This entry has been updated (OED Third Edition, September 2009; most recently modified version published online March 2022).
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