protriptylinen.

Brit.

/prəʊˈtrɪptᵻliːn/, U.S.

/proʊˈtrɪptəl(ə)n/

Forms: 1900s– protriptyline, 1900s– protryptyline (irregular).

Origin: Formed within English, by compounding. Etymons: propyl n., amitriptyline n.

Etymology: < pro- (in propyl n.) + -triptyline (in amitriptyline n.).

Pharmacology.

A tricyclic antidepressant which is a derivative of amitriptyline.Chemical name: N-methyl-5H-dibenzo[a, d]cycloheptene-5-propanamine; C₁₉H₂₁N.

ΘΚΠ

the world > health and disease > healing > medicines or physic > medicines for specific purpose > medicine for mental conditions > [noun] > antidepressant > specific drugs

Marsilid1952

iproniazid1953

levallorphan1953

imipramine1958

Tofranil1958

isocarboxazid1959

Marplan1959

Nardil1959

nialamide1959

Niamid1959

phenelzine1959

tranylcypromine1959

Parnate1960

amitriptyline1961

monoamine oxidase inhibitor1962

nortriptyline1962

protriptyline1963

MAOI1965

maprotiline1970

mianserin1970

amoxapine1971

fluoxetine1975

paroxetine1977

Prozac1985

Seroxat1985

1963 Amer. Jrnl. Psychiatry 120 594/1 In an attempt to evaluate a derivative of amitriptyline, MK-240 (protryptyline), where the ‘sleepiness’ was removed by a change in the chemical formula, the drug was studied in 61 patients with various types of depression.

1978 Nature 23 Mar. 330/1 The tricyclic anti~depressant drugs which are tertiary amines..were more potent inhibitors than those which are secondary amines (desmethylimipramine, nortriptyline, protriptyline).

1989 Adverse Drug Reactions & Acute Poisoning Rev. 8 27 Elimination of tricyclic antidepressants is slow: elimination half-lives range from about 16 hours for amitriptyline to 80 hours for protriptyline at therapeutic doses.

2004 Drugs 64 1385 Most of the drugs have been found to be ineffective [in obstructive sleep apnoea] and those that have worked for some patients (acetazolamide and protriptyline) have produced intolerable adverse effects.

This entry has been updated (OED Third Edition, September 2007; most recently modified version published online March 2022).

单词	protriptyline
释义	protriptylinen. Brit. /prəʊˈtrɪptᵻliːn/, U.S. /proʊˈtrɪptəl(ə)n/ Forms: 1900s– protriptyline, 1900s– protryptyline (irregular). Origin: Formed within English, by compounding. Etymons: propyl n., amitriptyline n. Etymology: < pro- (in propyl n.) + -triptyline (in amitriptyline n.). Pharmacology. A tricyclic antidepressant which is a derivative of amitriptyline.Chemical name: N-methyl-5H-dibenzo[a, d]cycloheptene-5-propanamine; C₁₉H₂₁N. ΘΚΠ the world > health and disease > healing > medicines or physic > medicines for specific purpose > medicine for mental conditions > [noun] > antidepressant > specific drugs Marsilid1952 iproniazid1953 levallorphan1953 imipramine1958 Tofranil1958 isocarboxazid1959 Marplan1959 Nardil1959 nialamide1959 Niamid1959 phenelzine1959 tranylcypromine1959 Parnate1960 amitriptyline1961 monoamine oxidase inhibitor1962 nortriptyline1962 protriptyline1963 MAOI1965 maprotiline1970 mianserin1970 amoxapine1971 fluoxetine1975 paroxetine1977 Prozac1985 Seroxat1985 1963 Amer. Jrnl. Psychiatry 120 594/1 In an attempt to evaluate a derivative of amitriptyline, MK-240 (protryptyline), where the ‘sleepiness’ was removed by a change in the chemical formula, the drug was studied in 61 patients with various types of depression. 1978 Nature 23 Mar. 330/1 The tricyclic anti~depressant drugs which are tertiary amines..were more potent inhibitors than those which are secondary amines (desmethylimipramine, nortriptyline, protriptyline). 1989 Adverse Drug Reactions & Acute Poisoning Rev. 8 27 Elimination of tricyclic antidepressants is slow: elimination half-lives range from about 16 hours for amitriptyline to 80 hours for protriptyline at therapeutic doses. 2004 Drugs 64 1385 Most of the drugs have been found to be ineffective [in obstructive sleep apnoea] and those that have worked for some patients (acetazolamide and protriptyline) have produced intolerable adverse effects. This entry has been updated (OED Third Edition, September 2007; most recently modified version published online March 2022). < n.1963
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