primosomen.
/ˈprʌɪməsəʊm/, U.S. /ˈpraɪməˌsoʊm/ Molecular Biology.
A complex of proteins, first identified in Eschericha coli, required for the initiation of DNA synthesis during the process of bacterial DNA replication.
ΚΠ
1981 K. Arai & A. Kornberg in Proc. National Acad. Sci. U.S.A. 78 69/1 The present work shows that complementary strand replication is in fact initiated at or near the protein n' recognition locus by a multiprotein DNA complex (a mobile replication promoter or ‘primosome’).
1989 B. Alberts et al. Molecular Biol. Cell (ed. 2) v. 233 (caption) The complex of the DNA primase and the DNA helicase on the lagging strand is known as the primosome.
2005 Molecular Cell 17 733/1 An ordered series of protein–protein interactions culminates in the loading of the primosome onto the single-stranded DNA binding protein (SSB)-coated phage chromosome.
This is a new entry (OED Third Edition, June 2007; most recently modified version published online March 2022).
<
n.1981