pralidoximen.

Brit.

/ˌpralᵻˈdɒksiːm/, U.S.

/ˌpræləˈdɑkˌsim/

Origin: Apparently formed within English, by compounding. Etymons: pyridine n., aldoxime n. at aldo- comb. form 2

Etymology: Apparently < p- and -r- (in pyridine n.) + al- (in aldoxime n. at aldo- comb. form 2) + -i- (in pyridine n.) + -doxime (in aldoxime n. at aldo- comb. form 2).

Pharmacology.

A drug used in conjunction with atropine as an antidote to poisoning by certain organophosphates, acting by dephosphorylating and reactivating the enzyme acetylcholinesterase.Pralidoxime is the chloride, iodide, or mesylate of a quaternary ammonium ion, 2-hydroxyiminomethyl-1-methylpyridinium, [HON=CH·C₅H₄N(CH₃)]⁺.

ΘΚΠ

the world > health and disease > healing > medicines or physic > medicines for specific purpose > antidote > [noun] > antidotes to chemical poisons

B.A.L.1942

dimercaprol1945

pralidoxime1961

1961 Approved Names (Brit. Pharmacopœia Comm.) 19 Pralidoxime Iodide, Picolinaldoxime methiodide, Protopam.

1974 M. C. Gerald Pharmacol. vii. 132 Normal cholinesterase activity is restored..when a cholinesterase reactivator, notably pralidoxime (2-PAM), is used as an antidote.

1978 Daily Tel. 23 Jan. 13/7 British soldiers and airmen are now equipped with pills which will enable them to survive three or four times the normal lethal dose of most nerve gases... The pills, produced from pralidoxime mesylate..are issued in batches for each 24 hours.

1995 Independent 21 Feb. 23/7 Soldiers in the 1992 Gulf war carried atropine and pralidoxime to inject themselves in the event of a nerve gas attack.

This entry has been updated (OED Third Edition, March 2007; most recently modified version published online March 2022).

单词	pralidoxime
释义	pralidoximen. Brit. /ˌpralᵻˈdɒksiːm/, U.S. /ˌpræləˈdɑkˌsim/ Origin: Apparently formed within English, by compounding. Etymons: pyridine n., aldoxime n. at aldo- comb. form 2 Etymology: Apparently < p- and -r- (in pyridine n.) + al- (in aldoxime n. at aldo- comb. form 2) + -i- (in pyridine n.) + -doxime (in aldoxime n. at aldo- comb. form 2). Pharmacology. A drug used in conjunction with atropine as an antidote to poisoning by certain organophosphates, acting by dephosphorylating and reactivating the enzyme acetylcholinesterase.Pralidoxime is the chloride, iodide, or mesylate of a quaternary ammonium ion, 2-hydroxyiminomethyl-1-methylpyridinium, [HON=CH·C₅H₄N(CH₃)]⁺. ΘΚΠ the world > health and disease > healing > medicines or physic > medicines for specific purpose > antidote > [noun] > antidotes to chemical poisons B.A.L.1942 dimercaprol1945 pralidoxime1961 1961 Approved Names (Brit. Pharmacopœia Comm.) 19 Pralidoxime Iodide, Picolinaldoxime methiodide, Protopam. 1974 M. C. Gerald Pharmacol. vii. 132 Normal cholinesterase activity is restored..when a cholinesterase reactivator, notably pralidoxime (2-PAM), is used as an antidote. 1978 Daily Tel. 23 Jan. 13/7 British soldiers and airmen are now equipped with pills which will enable them to survive three or four times the normal lethal dose of most nerve gases... The pills, produced from pralidoxime mesylate..are issued in batches for each 24 hours. 1995 Independent 21 Feb. 23/7 Soldiers in the 1992 Gulf war carried atropine and pralidoxime to inject themselves in the event of a nerve gas attack. This entry has been updated (OED Third Edition, March 2007; most recently modified version published online March 2022). < n.1961
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