phenindionen.
/ˌfɛnᵻnˈdʌɪəʊn/, U.S. /ˌfɛnənˈdaɪˌoʊn/ Pharmacology.
An anticoagulant drug having a structural analogy to vitamin K, used esp. in the treatment of thrombosis.Chemical name: 2-phenylindan-1,3-dione, C15H10O2.
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the world > health and disease > healing > medicines or physic > medicines for specific purpose > preparations for treating specific parts > [noun] > for the blood > anti-coagulants
anti-coagulant1905
heparin1918
Tromexan1949
warfarin1950
phenindione1955
ticlopidine1975
clopidogrel1989
1955 Proc. Soc. Exper. Biol. & Med. 89 81/1 In an investigation of the effect of phenindione (PID) on the coagulation mechanism.., it was discovered that patients who had received this anticoagulant for more than about 30 days developed a distinctly prolonged glass clotting time.
1962 Lancet 13 Jan. 104/2 Treatment with heparin and phenindione was begun, but after six hours the patient suddenly became unconscious and pulseless, though slow voluntary respirations persisted.
1974 R. H. Hammer in W. O. Foye Princ. Med. Chem. xviii. 409/1 Phenindione is the most commonly used 1,3-indandione anticoagulant... The chief disadvantage of phenindione is its toxic side effects.
1992 Med. Anthropol. Q. 6 105 Drugs that change the color of urine to red or red-orange, such as anisindione, phenindione.
This entry has been updated (OED Third Edition, December 2005; most recently modified version published online March 2022).
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n.1955