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单词 michaelis–menten
释义

Michaelis–Mentenn.

Brit. /mᵻˌkeɪlɪsˈmɛnt(ə)n/, U.S. /məˌkeɪləsˈmɛn(t)ən/
Origin: From proper names. Etymons: proper names Michaelis, Menten.
Etymology: < the names of Leonor Michaelis (see Michaelis constant n.) and Maud Lenore Menten (1879–1960), Canadian-born American physician, whose collaborative work resulted in a model of enzyme action, published in Biochem. Zeitschrift 49 333 (1913).
Biochemistry.
attributive. Designating or relating to a model of enzyme action which assumes the formation of an intermediate complex of enzyme and substrate, and the kinetic properties associated with this model.
ΘΚΠ
the world > life > biology > biological processes > genetic activity > genetic components > [adjective] > of nucleic acid > of enzymes
constitutive1932
Michaelis–Menten1934
inducible1953
angiotensinase1958
1925 Biochem. Jrnl. 19 339 This is Michaelis and Menten's equation, (k2 + k3)/k1 representing their constant Ks.]
1934 New Phytologist 33 24 Assuming that the catalyst obeys the Michaelis-Menten rule, i.e. that the first reaction is relatively fast, the net rate would be given by the expression [etc.].
1947 J. B. Sumner & G. F. Somers Chem. & Methods Enzymes (ed. 2) i. 20 The Michaelis–Menten hypothesis has also been extended to include equilibria involving enzyme, coenzyme, substrate, and hydrogen ions.
1954 H. B. Bull in W. D. McElroy & B. Glass Symp. on Mechanism of Enzyme Action ii. 141 The Michaelis–Menten rate expression is a composite equation combining zero- and first-order kinetics.
1984 S. D. Shorvon Epilepsy 21/2 The best example of this is that of phenytoin, which exhibits Michaelis–Menten kinetics, often with a steeply rising curve at serum levels which are clinically important.
1990 Jrnl. Exper. Bot. 41 930/1 The deterioration in photosynthetic performance can be predicted from simple Michaelis–Menten kinetics..for two competitive substrates.
2000 Life Sci. 67 175 The kinetics of chlorpromazine 7-hydroxylation in human liver microsomes showed a simple Michaelis-Menten behavior.
This entry has been updated (OED Third Edition, December 2001; most recently modified version published online March 2022).
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n.1934
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