mediatorn.

Brit.

/ˈmiːdɪeɪtə/, U.S.

/ˈmidiˌeɪdər/

Forms: Middle English mediater, Middle English mediatowr, Middle English mediatowre, Middle English mediatur, Middle English mediature, Middle English medyatowre, Middle English medyatur, Middle English medyature, Middle English medytur (perhaps transmission error), Middle English–1500s mediatoure, Middle English–1500s medyator, Middle English–1500s medyatour, Middle English–1600s mediatour, 1500s medyatoure, 1500s– mediator; Scottish pre-1700 medeator, pre-1700 medeatour, pre-1700 mediateur, pre-1700 mediatore, pre-1700 mediatour, pre-1700 mediatoure, pre-1700 mediatur, pre-1700 medieatour, pre-1700 medyatour, pre-1700 medyatowre, pre-1700 medyature, pre-1700 1700s– mediator.

Origin: Either (i) a borrowing from French. Or (ii) a borrowing from Latin. Etymons: French mediatur, mediateur; Latin mediātor.

Etymology: < Anglo-Norman mediatur, mediatour and Middle French mediateur (early 14th cent. in Old French as mediatour ; French médiateur (1694)) or their etymon classical Latin mediātor (2nd cent.) < medius middle (see medium adj.) + -ātor -ator suffix; compare slightly later post-classical Latin mediare mediate v. Compare Italian mediatore (1304), Spanish mediador (1425), Portuguese mediador, mediator (both 17th cent.).Although it appears once in a late classical author (Apuleius), most of the earliest examples of Latin mediator occur in Christian and theological sources, representing ancient Greek μεσίτης (see mesite n.), used in Hellenistic Greek in the New Testament specifically to refer to Christ as an intermediary between God and man. With sense 4 compare Spanish mediator (1774) and mediateur n.

a. Theology. An intermediary between God and humankind, spec. Jesus (cf. 1 Timothy 2:5).

ΘΚΠ

the world > the supernatural > deity > Christian God > [noun] > mediator between God and man

thingerOE

meana1382

mediatorc1384

intercessora1530

the world > the supernatural > deity > Christian God > the Trinity > the Son or Christ > [noun] > according to other attributes

horn of salvation (health)c825

fatherOE

sun of righteousnessOE

priestc1175

leecha1200

vinec1315

apostlec1382

amenc1384

shepherdc1384

the Wisdom of the Father1402

high priest1526

pelican1526

mediatora1530

reconcilerc1531

branch1535

morning star1535

surety1535

vicar1651

arch-shepherd1656

hierarch1855

particularity1930

c1384 Bible (Wycliffite, E.V.) (Douce 369(2)) (1850) 1 Tim. ii. 5 O God and mediatour of God and men.

c1384 Bible (Wycliffite, E.V.) (Douce 369(2)) Gal. iii. 20 For trespassynge it is putt, til the seed cam, to whom God bihiȝte thingis ordeyned by aungelis, in the hond of a medyatour.

a1400 (a1325) Cursor Mundi (Fairf. 14) 27503 Þou has me [sc. the confessor] made a mediatour, als mediatour & messagere, twix ham & þe þaire erande bere.

a1450 in C. Brown Relig. Lyrics 15th Cent. (1939) 32 (MED) Thorugh meuynge of þat mayden mere, Þat mediatur is made in men.

a1513 J. Irland Meroure of Wyssdome (1926) I. 119 For he mon be werray mediatore and pece makare betuix God and man.

a1530 W. Bonde Pylgrimage of Perfeccyon (1531) f. 190^v Sauyour & mediatour of mankynde.

1649 E. Reynolds Israels Prayer (new ed.) i. 41 The Prophet here secretly leadeth us to Christ the Mediatour.

1667 J. Milton Paradise Lost xii. 240 Instructed that to God is no access Without Mediator .

1736 Bp. J. Butler Analogy of Relig. ii. v. 194 There is then no Sort of Objection, from the Light of Nature, against the general Notion of a Mediator between God and Man.

1813 C. Anderson Let. 14 June in H. Anderson Life & Lett. C. Anderson (1854) v. 136 Here were a few..praying before..St. Peter..and the Virgin and Child, looking to mediators who cannot save.

1849 R. I. Wilberforce Doctr. Holy Baptism (1850) 18 It was the Second, not the Third Person of the Ever-blessed Trinity who became the Incarnate Mediator.

1902 A. B. Davidson Biblical & Lit. Ess. 247 These saints as intercessors and mediators bridge over the chasm that separates God from man.

1994 30 Days in Church & in World No. 4. 72/3 Or through any other means which is not the merit of the sole mediator, our Savior Jesus Christ.

b. gen. A person who intervenes between two parties, esp. for the purpose of effecting reconciliation; an intercessor; a person who brings about an agreement, treaty, etc., or settles a dispute by mediation.

ΘΚΠ

the world > action or operation > easiness > aid, help, or assistance > intercession or influence on someone's behalf > [noun] > one who

forespeakerc1175

sequesterc1380

meanc1384

meanera1387

mediatorc1410

advocatec1450

intercessor1482

advowrer1508

attorney1537

paranympha1538

paraclete?1548

advocator1588

intercedera1656

intercedenta1661

supercargo1713

citizen advocate1958

society > armed hostility > peace > pacification > peace treaty > [noun] > mediator

mediatorc1410

treater1489

parlementaire1853

parliamentary1855

shuttle diplomat1977

society > society and the community > dissent > absence of dissension or peace > bringing about concord or peace > [noun] > settling quarrels or disputes > mediation > mediator

mediatorc1410

recounsellera1425

mid-man1459

stiffler1473

stickler1538

goer1548

ombudsman1970

c1410 tr. R. Higden Polychron. (St. John's Cambr.) (1879) VII. 125 Mediatours goynge bytwixe, pees was made.

c1460 in A. Clark Eng. Reg. Oseney Abbey (1907) 58 (MED) At þe laste, by..mediatours bytwene þem, all þe saide controuersies whare i-sesed frendely for Euer.

1483 ( tr. G. Deguileville Pilgrimage of Soul (Caxton) (1859) iv. xxxiii. 79^v This ryal lordes be meanes and mediatoures betwyn the kyng and his peopil in euery nede.

1554 Act 1 & 2 Philip & Mary c. 8 §9 It maie please yo^r Majesties to be Intercessours and Mediatours to..Cardinall Poole.

1606 F. Pulton Kalender of Statutes f. 18^v And two English men, two of Lombardie, and two of Almaigne shall chosen to be Mediators of questions between sellers and buiers.

1609 S. Daniel Civile Wares (rev. ed.) viii. liii. 217 And, in deliv'ring it, lifts vp her eyes (The mouingst Mediatours shee could bring).

c1615 F. Bacon Advice to G. Villiers in Wks. (1879) I. 509/1 The trouble of all men's confluence..to yourself, as a mediator between them and their sovereign.

1632 Swedish Intelligencer i. 6 The King of Denmarke the Mediator of the Peace.

1769 W. Robertson Hist. Charles V III. x. 251 The Princes who were present..acted as intercessors or mediators between them.

1855 H. H. Milman Hist. Lat. Christianity IV. ix. xiv. 377 The lofty station of mediator of such peace became his sacred function.

1872 J. H. Newman Hist. Sketches I. ii. iv. 258 He claimed for himself especially the part of mediator between political rivals.

1910 Encycl. Brit. I. 179/1 The Russian government suggested that the tsar was willing to act as mediator between the two belligerents.

1988 Which? Mar. 109/1 Mediators aim to solve problems amicably.

†2. A go-between; a messenger, agent. Obsolete.

ΘΚΠ

the world > action or operation > advantage > usefulness > use (made of things) > instrumentality > [noun] > intermediate agency > intermediate means > person as

dealerc1000

meanc1384

mediatorc1390

moyen1455

intermediator1522

broker1530

middlera1533

intercessor1554

mercury1602

intermedial1605

transactor1611

interdealer1613

intermeddler1630

intercommuner1638

middleman1648

second hand1655

inter-agent1728

intermediary1791

in-between1815

medium1817

intermediate1879

come-between1919

tolkach1955

c1390 G. Chaucer Parson's Tale 967 By whiche mediatours or by whiche messagers, as for enticement or for consentement to bere compaignye with felaweshipe.

c1480 (a1400) St. Andrew 1063 in W. M. Metcalfe Legends Saints Sc. Dial. (1896) I. 94 Þane he þat mediatoure had bene, and hard þis answere all bedene, recordyt it to þe bischope.

1508 Golagros & Gawane (Chepman & Myllar) sig. bii Our souerane Arthour..Has maid ws thre as mediatour His message to schaw.

1576 A. Fleming tr. P. Manutius in Panoplie Epist. 331 Your highnesse, whom it hath pleased..voluntarily (without the helpe of any mediatour) to graunt mee free..accesse to your friendshippe.

1622 G. de Malynes Consuetudo 98 A Merchant, hauing many of these Billes..will resort vnto..another Merchant, commonly accompanied with a Mediator or Broker.

1697 in Syllabus Rymer's Fœdera (1869) Pref. 112 The French had received our ratification under the signett, and putt it collationed into the mediatours hands.

a. An intermediate agent; something which effects a transition between one stage or state and another; (Psychology) an agent in mediation (mediation n. 2b), an intermediate mental process or cognitive activity.

ΘΚΠ

the mind > mental capacity > psychology > experimental psychology > stimulus-response > [noun] > mediation > agent in

mediatorc1475

c1475 ( Surg. Treat. in MS Wellcome 564 f. 26 (MED) Þe eir..is a nedeful mediatour to bere þe spicis of þe spirit of smellynges.

1605 T. Tymme tr. J. Du Chesne Pract. Chymicall & Hermeticall Physicke iii. 144 The whaye of the blood is as a chariot or mediator, and combiner of the other two beginnings together.

1854 J. S. Bigg Night & Soul xi. 136 Ruddy sunbeams, radiant with haste.., Bright mediators between earth and heaven.

1953 C. E. Osgood Method & Theory Exper. Psychol. iii. ix. 402 The self-stimulation produced by mediators.

1965 Language 41 139 Such words as istorik, istorija.., which appear already in Old Russian literature, are justly regarded by her as direct borrowings from Greek or Latin, and not as mediated by other languages... On the other hand, the more detailed data obtained on foreign words have enabled Mrs. Worth to correct and to define more precisely the role of the mediator languages, especially that of Polish.

1970 N. E. Spear in M. R. D'Amato Exper. Psychol. xii. 604 S's consequential use of potential mediators for learning.

1970 Jrnl. Gen. Psychol. 83 5 Rhine also furthers his analysis to the affect-arousal components that certain verbal mediators may eventually elicit.

1991 Times Educ. Suppl. 18 Jan. 29/3 Poor readers who demonstrate a strong visual processing preference can be taught more successfully through strategies which employ a morphographic regimen using visual mediators (known as icons) rather than by phonics.

b. Medicine. An antibody that produces haemolysis. rare.

ΘΚΠ

the world > life > biology > substance > process stimulators or inhibitors > antibody > [noun] > specific type of

mediator1903

reagin1915

spectrotype1974

1903 A. S. Grünbaum in Brit. Med. Jrnl. 21 Mar. 654 Ehrlich..recognized..that Bordet was right in assuming the existence of two bodies for the production of this phenomenon [sc. haemolysis], and that one body (mediator, amboceptor) was present in quantity in the serum of immunized animals only, while the other (the complement) occurred in the serum of normal untreated animals.

1903 Brit. Med. Jrnl. 4 Apr. 784 The immune serum merely contains an excess of normal mediators and not new ones.

c. Physiology and Chemistry. An enzyme, hormone, or other chemical substance which acts as an intermediate or carrier in, or otherwise influences, a chemical, physiological, or pathological process.

ΚΠ

1956 Histamine: Ciba Found. Symp. 1955 280 The second fact appears to exclude histamine as a mediator for the posterior root vasodilator fibres.

1958 Pharmacol. Rev. 10 489 It seems at the moment that the importance of 5- ht as a ‘mediator’ of altered vascular permeability in inflammation is likely to be confined to certain tissues, perhaps only the skin, of the rat and possibly of the mouse.

1966 Arch. Dermatol. 93 601/1 A mediator may be defined as an endogenous chemical agent which takes an active part in the development of the inflammatory response.

1986 C. W. Thornber in C. A. Heaton Chem. Industry iv. 193 Because histamine is a mediator of bronchospasm produced in allergic reactions, histamine antagonists are used prophylactically for hay fever.

1995 New Scientist 17 June 26/1 The sample is bathed in an electrolyte solution called a mediator, which exchanges electrons with the electrodes, thus generating an electric current.

d. Particle Physics. A subatomic ‘carrier’ of one of the four known kinds of force, which by travelling between an emitting and a receiving particle enables the former to affect the latter.

ΚΠ

1968 Physical Rev. 176 1846 A suggestion by Schwinger to use a scalar bason as mediator of weak interactions is combined with a proposal by Nishijima to consider the weak interactions as second-order effects of an interaction with no first-order manifestations.

1981 A. Salam in J. H. Mulvey Nature of Matter v. 116 The charged mediators W⁺ and W⁻ with masses about 80 GeV should also be produced.

1989 Sci. Amer. Oct. 39/1 Three kinds of mediators are now known to exist: photons, gluons and weak-force mediators. They correspond to three of the four forces in nature.

4. Cards. A variation in the games of ombre and quadrille.

ΘΚΠ

society > leisure > entertainment > pastimes > game > card game > ombre and quadrille > [noun] > varieties of

renegado1674

penny-ombre1710

quintille?1720

tresillo1829

mediator1902

1902 Ld. Aldenham Game of Ombre (ed. 3) 6 Quadrille, Quintille, Piquemedrille, Tredrille, Sextille, and Mediator, which are all variations of the Game of Ombre.

This entry has been updated (OED Third Edition, June 2001; most recently modified version published online June 2022).

单词	mediator
释义	mediatorn. Brit. /ˈmiːdɪeɪtə/, U.S. /ˈmidiˌeɪdər/ Forms: Middle English mediater, Middle English mediatowr, Middle English mediatowre, Middle English mediatur, Middle English mediature, Middle English medyatowre, Middle English medyatur, Middle English medyature, Middle English medytur (perhaps transmission error), Middle English–1500s mediatoure, Middle English–1500s medyator, Middle English–1500s medyatour, Middle English–1600s mediatour, 1500s medyatoure, 1500s– mediator; Scottish pre-1700 medeator, pre-1700 medeatour, pre-1700 mediateur, pre-1700 mediatore, pre-1700 mediatour, pre-1700 mediatoure, pre-1700 mediatur, pre-1700 medieatour, pre-1700 medyatour, pre-1700 medyatowre, pre-1700 medyature, pre-1700 1700s– mediator. Origin: Either (i) a borrowing from French. Or (ii) a borrowing from Latin. Etymons: French mediatur, mediateur; Latin mediātor. Etymology: < Anglo-Norman mediatur, mediatour and Middle French mediateur (early 14th cent. in Old French as mediatour ; French médiateur (1694)) or their etymon classical Latin mediātor (2nd cent.) < medius middle (see medium adj.) + -ātor -ator suffix; compare slightly later post-classical Latin mediare mediate v. Compare Italian mediatore (1304), Spanish mediador (1425), Portuguese mediador, mediator (both 17th cent.).Although it appears once in a late classical author (Apuleius), most of the earliest examples of Latin mediator occur in Christian and theological sources, representing ancient Greek μεσίτης (see mesite n.), used in Hellenistic Greek in the New Testament specifically to refer to Christ as an intermediary between God and man. With sense 4 compare Spanish mediator (1774) and mediateur n. 1. a. Theology. An intermediary between God and humankind, spec. Jesus (cf. 1 Timothy 2:5). ΘΚΠ the world > the supernatural > deity > Christian God > [noun] > mediator between God and man thingerOE meana1382 mediatorc1384 intercessora1530 the world > the supernatural > deity > Christian God > the Trinity > the Son or Christ > [noun] > according to other attributes horn of salvation (health)c825 fatherOE sun of righteousnessOE priestc1175 leecha1200 vinec1315 apostlec1382 amenc1384 shepherdc1384 the Wisdom of the Father1402 high priest1526 pelican1526 mediatora1530 reconcilerc1531 branch1535 morning star1535 surety1535 vicar1651 arch-shepherd1656 hierarch1855 particularity1930 c1384 Bible (Wycliffite, E.V.) (Douce 369(2)) (1850) 1 Tim. ii. 5 O God and mediatour of God and men. c1384 Bible (Wycliffite, E.V.) (Douce 369(2)) Gal. iii. 20 For trespassynge it is putt, til the seed cam, to whom God bihiȝte thingis ordeyned by aungelis, in the hond of a medyatour. a1400 (a1325) Cursor Mundi (Fairf. 14) 27503 Þou has me [sc. the confessor] made a mediatour, als mediatour & messagere, twix ham & þe þaire erande bere. a1450 in C. Brown Relig. Lyrics 15th Cent. (1939) 32 (MED) Thorugh meuynge of þat mayden mere, Þat mediatur is made in men. a1513 J. Irland Meroure of Wyssdome (1926) I. 119 For he mon be werray mediatore and pece makare betuix God and man. a1530 W. Bonde Pylgrimage of Perfeccyon (1531) f. 190^v Sauyour & mediatour of mankynde. 1649 E. Reynolds Israels Prayer (new ed.) i. 41 The Prophet here secretly leadeth us to Christ the Mediatour. 1667 J. Milton Paradise Lost xii. 240 Instructed that to God is no access Without Mediator . View more context for this quotation 1736 Bp. J. Butler Analogy of Relig. ii. v. 194 There is then no Sort of Objection, from the Light of Nature, against the general Notion of a Mediator between God and Man. 1813 C. Anderson Let. 14 June in H. Anderson Life & Lett. C. Anderson (1854) v. 136 Here were a few..praying before..St. Peter..and the Virgin and Child, looking to mediators who cannot save. 1849 R. I. Wilberforce Doctr. Holy Baptism (1850) 18 It was the Second, not the Third Person of the Ever-blessed Trinity who became the Incarnate Mediator. 1902 A. B. Davidson Biblical & Lit. Ess. 247 These saints as intercessors and mediators bridge over the chasm that separates God from man. 1994 30 Days in Church & in World No. 4. 72/3 Or through any other means which is not the merit of the sole mediator, our Savior Jesus Christ. b. gen. A person who intervenes between two parties, esp. for the purpose of effecting reconciliation; an intercessor; a person who brings about an agreement, treaty, etc., or settles a dispute by mediation. ΘΚΠ the world > action or operation > easiness > aid, help, or assistance > intercession or influence on someone's behalf > [noun] > one who forespeakerc1175 sequesterc1380 meanc1384 meanera1387 mediatorc1410 advocatec1450 intercessor1482 advowrer1508 attorney1537 paranympha1538 paraclete?1548 advocator1588 intercedera1656 intercedenta1661 supercargo1713 citizen advocate1958 society > armed hostility > peace > pacification > peace treaty > [noun] > mediator mediatorc1410 treater1489 parlementaire1853 parliamentary1855 shuttle diplomat1977 society > society and the community > dissent > absence of dissension or peace > bringing about concord or peace > [noun] > settling quarrels or disputes > mediation > mediator mediatorc1410 recounsellera1425 mid-man1459 stiffler1473 stickler1538 goer1548 ombudsman1970 c1410 tr. R. Higden Polychron. (St. John's Cambr.) (1879) VII. 125 Mediatours goynge bytwixe, pees was made. c1460 in A. Clark Eng. Reg. Oseney Abbey (1907) 58 (MED) At þe laste, by..mediatours bytwene þem, all þe saide controuersies whare i-sesed frendely for Euer. 1483 ( tr. G. Deguileville Pilgrimage of Soul (Caxton) (1859) iv. xxxiii. 79^v This ryal lordes be meanes and mediatoures betwyn the kyng and his peopil in euery nede. 1554 Act 1 & 2 Philip & Mary c. 8 §9 It maie please yo^r Majesties to be Intercessours and Mediatours to..Cardinall Poole. 1606 F. Pulton Kalender of Statutes f. 18^v And two English men, two of Lombardie, and two of Almaigne shall chosen to be Mediators of questions between sellers and buiers. 1609 S. Daniel Civile Wares (rev. ed.) viii. liii. 217 And, in deliv'ring it, lifts vp her eyes (The mouingst Mediatours shee could bring). c1615 F. Bacon Advice to G. Villiers in Wks. (1879) I. 509/1 The trouble of all men's confluence..to yourself, as a mediator between them and their sovereign. 1632 Swedish Intelligencer i. 6 The King of Denmarke the Mediator of the Peace. 1769 W. Robertson Hist. Charles V III. x. 251 The Princes who were present..acted as intercessors or mediators between them. 1855 H. H. Milman Hist. Lat. Christianity IV. ix. xiv. 377 The lofty station of mediator of such peace became his sacred function. 1872 J. H. Newman Hist. Sketches I. ii. iv. 258 He claimed for himself especially the part of mediator between political rivals. 1910 Encycl. Brit. I. 179/1 The Russian government suggested that the tsar was willing to act as mediator between the two belligerents. 1988 Which? Mar. 109/1 Mediators aim to solve problems amicably. †2. A go-between; a messenger, agent. Obsolete. ΘΚΠ the world > action or operation > advantage > usefulness > use (made of things) > instrumentality > [noun] > intermediate agency > intermediate means > person as dealerc1000 meanc1384 mediatorc1390 moyen1455 intermediator1522 broker1530 middlera1533 intercessor1554 mercury1602 intermedial1605 transactor1611 interdealer1613 intermeddler1630 intercommuner1638 middleman1648 second hand1655 inter-agent1728 intermediary1791 in-between1815 medium1817 intermediate1879 come-between1919 tolkach1955 c1390 G. Chaucer Parson's Tale 967 By whiche mediatours or by whiche messagers, as for enticement or for consentement to bere compaignye with felaweshipe. c1480 (a1400) St. Andrew 1063 in W. M. Metcalfe Legends Saints Sc. Dial. (1896) I. 94 Þane he þat mediatoure had bene, and hard þis answere all bedene, recordyt it to þe bischope. 1508 Golagros & Gawane (Chepman & Myllar) sig. bii Our souerane Arthour..Has maid ws thre as mediatour His message to schaw. 1576 A. Fleming tr. P. Manutius in Panoplie Epist. 331 Your highnesse, whom it hath pleased..voluntarily (without the helpe of any mediatour) to graunt mee free..accesse to your friendshippe. 1622 G. de Malynes Consuetudo 98 A Merchant, hauing many of these Billes..will resort vnto..another Merchant, commonly accompanied with a Mediator or Broker. 1697 in Syllabus Rymer's Fœdera (1869) Pref. 112 The French had received our ratification under the signett, and putt it collationed into the mediatours hands. 3. a. An intermediate agent; something which effects a transition between one stage or state and another; (Psychology) an agent in mediation (mediation n. 2b), an intermediate mental process or cognitive activity. ΘΚΠ the mind > mental capacity > psychology > experimental psychology > stimulus-response > [noun] > mediation > agent in mediatorc1475 c1475 ( Surg. Treat. in MS Wellcome 564 f. 26 (MED) Þe eir..is a nedeful mediatour to bere þe spicis of þe spirit of smellynges. 1605 T. Tymme tr. J. Du Chesne Pract. Chymicall & Hermeticall Physicke iii. 144 The whaye of the blood is as a chariot or mediator, and combiner of the other two beginnings together. 1854 J. S. Bigg Night & Soul xi. 136 Ruddy sunbeams, radiant with haste.., Bright mediators between earth and heaven. 1953 C. E. Osgood Method & Theory Exper. Psychol. iii. ix. 402 The self-stimulation produced by mediators. 1965 Language 41 139 Such words as istorik, istorija.., which appear already in Old Russian literature, are justly regarded by her as direct borrowings from Greek or Latin, and not as mediated by other languages... On the other hand, the more detailed data obtained on foreign words have enabled Mrs. Worth to correct and to define more precisely the role of the mediator languages, especially that of Polish. 1970 N. E. Spear in M. R. D'Amato Exper. Psychol. xii. 604 S's consequential use of potential mediators for learning. 1970 Jrnl. Gen. Psychol. 83 5 Rhine also furthers his analysis to the affect-arousal components that certain verbal mediators may eventually elicit. 1991 Times Educ. Suppl. 18 Jan. 29/3 Poor readers who demonstrate a strong visual processing preference can be taught more successfully through strategies which employ a morphographic regimen using visual mediators (known as icons) rather than by phonics. b. Medicine. An antibody that produces haemolysis. rare. ΘΚΠ the world > life > biology > substance > process stimulators or inhibitors > antibody > [noun] > specific type of mediator1903 reagin1915 spectrotype1974 1903 A. S. Grünbaum in Brit. Med. Jrnl. 21 Mar. 654 Ehrlich..recognized..that Bordet was right in assuming the existence of two bodies for the production of this phenomenon [sc. haemolysis], and that one body (mediator, amboceptor) was present in quantity in the serum of immunized animals only, while the other (the complement) occurred in the serum of normal untreated animals. 1903 Brit. Med. Jrnl. 4 Apr. 784 The immune serum merely contains an excess of normal mediators and not new ones. c. Physiology and Chemistry. An enzyme, hormone, or other chemical substance which acts as an intermediate or carrier in, or otherwise influences, a chemical, physiological, or pathological process. ΚΠ 1956 Histamine: Ciba Found. Symp. 1955 280 The second fact appears to exclude histamine as a mediator for the posterior root vasodilator fibres. 1958 Pharmacol. Rev. 10 489 It seems at the moment that the importance of 5- ht as a ‘mediator’ of altered vascular permeability in inflammation is likely to be confined to certain tissues, perhaps only the skin, of the rat and possibly of the mouse. 1966 Arch. Dermatol. 93 601/1 A mediator may be defined as an endogenous chemical agent which takes an active part in the development of the inflammatory response. 1986 C. W. Thornber in C. A. Heaton Chem. Industry iv. 193 Because histamine is a mediator of bronchospasm produced in allergic reactions, histamine antagonists are used prophylactically for hay fever. 1995 New Scientist 17 June 26/1 The sample is bathed in an electrolyte solution called a mediator, which exchanges electrons with the electrodes, thus generating an electric current. d. Particle Physics. A subatomic ‘carrier’ of one of the four known kinds of force, which by travelling between an emitting and a receiving particle enables the former to affect the latter. ΚΠ 1968 Physical Rev. 176 1846 A suggestion by Schwinger to use a scalar bason as mediator of weak interactions is combined with a proposal by Nishijima to consider the weak interactions as second-order effects of an interaction with no first-order manifestations. 1981 A. Salam in J. H. Mulvey Nature of Matter v. 116 The charged mediators W⁺ and W⁻ with masses about 80 GeV should also be produced. 1989 Sci. Amer. Oct. 39/1 Three kinds of mediators are now known to exist: photons, gluons and weak-force mediators. They correspond to three of the four forces in nature. 4. Cards. A variation in the games of ombre and quadrille. ΘΚΠ society > leisure > entertainment > pastimes > game > card game > ombre and quadrille > [noun] > varieties of renegado1674 penny-ombre1710 quintille?1720 tresillo1829 mediator1902 1902 Ld. Aldenham Game of Ombre (ed. 3) 6 Quadrille, Quintille, Piquemedrille, Tredrille, Sextille, and Mediator, which are all variations of the Game of Ombre. This entry has been updated (OED Third Edition, June 2001; most recently modified version published online June 2022). < n.c1384
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