lipstatinn.
/lɪpˈstatɪn/, U.S. /lɪpˈstætn/ Biochemistry.
A compound of the beta-lactone class which is produced by the bacterium Streptomyces toxytricini, and is a natural inhibitor of gastric and pancreatic carboxyl ester lipase.
ΚΠ
1987 E. K. Weibel et al. in Jrnl. Antibiotics 40 1086 Lipstatin, a new and very potent inhibitor of pancreatic lipase (the key enzyme of intestinal fat digestion) was isolated from Streptomyces toxytricini.
1989 Guardian (Nexis) 1 Mar. A more important problem is that lipstatin inhibits absorption of the fat-soluble vitamins A,D,E, and K.
2002 Jrnl. Org. Chem. 67 2257 Three putative intermediates in the biosynthesis of the lipase inhibitor lipstatin were synthesized in stable isotope-labeled form and were added to fermentation cultures of Streptomyces toxytricini.
This is a new entry (OED Third Edition, September 2004; most recently modified version published online March 2022).
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n.1987