fludrocortisonen.
/ˌfluːdrəʊˈkɔːtɪzəʊn/ Pharmacology.
A synthetic derivative (C21H29FO5) of hydrocortisone which causes retention of sodium and loss of potassium and which is given orally in the treatment of adrenocortical deficiency and to supplement cortisone in the treatment of Addison's disease; also elliptical for the acetate, the form in which the drug is usually given.
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the world > health and disease > healing > medicines or physic > medical preparations of specific origin > hormones and substances with same effect > [noun]
epinephrine1899
pituitrin1909
oxytocin1927
Pitocin1929
Pitressin1929
progestin1930
progesterone1935
methyltestosterone1936
pregnenolone1936
hexœstrol1939
stilboestrol1939
hydroxyprogesterone1941
progestogen1941
Premarin1942
hydroxycorticosterone1943
gestagen1948
hydrocortisone1951
cortisol1953
fluorohydrocortisone1954
isophane1954
prednisolone1955
prednisone1955
norethisterone1956
norethynodrel1957
dexamethasone1958
fludrocortisone1958
norethindrone1960
antidiuretic hormone1961
medroxyprogesterone1962
Pergonal1963
mesterolone1965
norgestrel1966
quinestrol1966
pancuronium1967
pentagastrin1967
levonorgestrel1977
1958 Clin. Sci. XVII. 205 These compounds differed from hydrocortisone only by the presence of an additional halogen atom, and fludrocortisone (9α-fluorohydrocortisone acetate) has proved to be the most active of the series.
1961 Lancet 25 Mar. 632/1 In the adrenalectomised subjects, aldosterone by mouth had 1/25th to 1/30th the potency of fludrocortisone in the maintenance of sodium balance.
1965 L. S. Goodman & A. Z. Gilman Pharmacol. Basis Therapeutics (ed. 3) lxxii. 1633 Fludrocortisone acetate..is the most potent synthetic mineralocorticoid.
1969 R. George in J. A. Bevan Essent. Pharmacol. xxxiv. 361 Fludrocortisone is used extensively as an anti-inflammatory agent but only in topical preparations.
This entry has not yet been fully updated (first published 1972; most recently modified version published online March 2019).
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n.1958