channelopathyn.
/tʃanəˈlɒpəθi/, U.S. /ˌtʃænəˈlɑpəθi/ Medicine.
Any of a diverse class of diseases or disorders caused by the dysfunction or impaired regulation of a particular type of membrane ion channel, esp. in nerve or muscle cells.Such disorders and diseases have a range of causes including genetic mutation (e.g. in cystic fibrosis) and autoimmune conditions (e.g. in myasthenia gravis).
ΚΠ
1993 Neuromuscular Disorders 3 161/1 As a consequence of this new knowledge the terms of skeletal muscle Cl− channel diseases (chloride channelopathies) and skeletal muscle Na+ channel diseases (sodium channelopathies) were coined.
2000 R. Tawil et al. in S.-M. Pulst Neurogenetics iii. 58/1 The presence of a characteristic muscle stiffness and myotonia make it [sc. Andersen's syndrome] a candidate for a channelopathy.
2015 N.Y. Times (Nexis) 10 Feb. 15 The bodies of otherwise healthy people who died suddenly, including infants, are tested for a group of potentially fatal heart diseases known as cardiac channelopathies.
This entry has been updated (OED Third Edition, June 2017; most recently modified version published online March 2022).
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n.1993