channelopathyn.

Brit.

/tʃanəˈlɒpəθi/, U.S.

/ˌtʃænəˈlɑpəθi/

Origin: Formed within English, by derivation. Etymons: channel n.¹, -o- connective, -pathy comb. form.

Etymology: < channel n.¹ + -o- connective + -pathy comb. form.

Medicine.

Any of a diverse class of diseases or disorders caused by the dysfunction or impaired regulation of a particular type of membrane ion channel, esp. in nerve or muscle cells.Such disorders and diseases have a range of causes including genetic mutation (e.g. in cystic fibrosis) and autoimmune conditions (e.g. in myasthenia gravis).

ΚΠ

1993 Neuromuscular Disorders 3 161/1 As a consequence of this new knowledge the terms of skeletal muscle Cl⁻ channel diseases (chloride channelopathies) and skeletal muscle Na⁺ channel diseases (sodium channelopathies) were coined.

2000 R. Tawil et al. in S.-M. Pulst Neurogenetics iii. 58/1 The presence of a characteristic muscle stiffness and myotonia make it [sc. Andersen's syndrome] a candidate for a channelopathy.

2015 N.Y. Times (Nexis) 10 Feb. 15 The bodies of otherwise healthy people who died suddenly, including infants, are tested for a group of potentially fatal heart diseases known as cardiac channelopathies.

This entry has been updated (OED Third Edition, June 2017; most recently modified version published online March 2022).

单词	channelopathy
释义	channelopathyn. Brit. /tʃanəˈlɒpəθi/, U.S. /ˌtʃænəˈlɑpəθi/ Origin: Formed within English, by derivation. Etymons: channel n.¹, -o- connective, -pathy comb. form. Etymology: < channel n.¹ + -o- connective + -pathy comb. form. Medicine. Any of a diverse class of diseases or disorders caused by the dysfunction or impaired regulation of a particular type of membrane ion channel, esp. in nerve or muscle cells.Such disorders and diseases have a range of causes including genetic mutation (e.g. in cystic fibrosis) and autoimmune conditions (e.g. in myasthenia gravis). ΚΠ 1993 Neuromuscular Disorders 3 161/1 As a consequence of this new knowledge the terms of skeletal muscle Cl⁻ channel diseases (chloride channelopathies) and skeletal muscle Na⁺ channel diseases (sodium channelopathies) were coined. 2000 R. Tawil et al. in S.-M. Pulst Neurogenetics iii. 58/1 The presence of a characteristic muscle stiffness and myotonia make it [sc. Andersen's syndrome] a candidate for a channelopathy. 2015 N.Y. Times (Nexis) 10 Feb. 15 The bodies of otherwise healthy people who died suddenly, including infants, are tested for a group of potentially fatal heart diseases known as cardiac channelopathies. This entry has been updated (OED Third Edition, June 2017; most recently modified version published online March 2022). < n.1993
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