| 释义 |
bleomycin, n. Pharm.|bliːəʊˈmaɪsɪn|
[Arbitrary alteration of earlier phleomycin, name of a related antibiotic, f. phleo-, of unknown origin + -mycin.]
An antineoplastic drug consisting of a glycopeptide or mixture of glycopeptides from the bacterium Streptomyces verticillus.
1966H. Umezawa in Antimicrobial Agents & Chemotherapy 1965 1080/2 An antibiotic complex produced by another strain of Streptomyces was more stable than phleomycin at acid and alkaline pH, but chelated with copper... This complex of the phleomycin group was named bleomycin. 1970Jrnl. Antibiotics XXIII. 473 The bleomycins, water-soluble basic glycopeptide antibiotics, produced by Streptomyces verticillus, exhibit antitumour and antibacterial activity... There are more than 13 bleomycins. 1979Sci. Amer. Aug. 33/3 The antitumor drug bleomycin..does its therapeutic work by damaging the DNA of tumor cells. 1981M. C. Gerald Pharmacol. (ed. 2) xxx. 586 With the exception of bleomycin, all other antitumor antibiotics..cause bone marrow depression. 1984Brit. Nat. Formulary viii. 269/1 Bleomycin is used to treat the lymphomas, certain solid tumours and..malignant effusions. |