释义 |
polymyxin Pharm.|pɒlɪˈmɪksɪn| Also polymixin. [f. mod.L. polymyxa, specific epithet (f. poly- + Gr. µύξα mucus, slime) + -in1.] Any of a class of antibiotics (polymyxin A, B, etc.) which are polypeptides obtained from strains of the soil bacterium Bacillus polymyxa and are used against Gram-negative bacteria in infections of the urinary tract and the skin.
1947P. G. Stansly et al. in Bull. Johns Hopkins Hosp. LXXXI. 43 The antibiotic-producing organism has been identified as Bacillus polymyxa and the antibiotic substance accordingly designated ‘Polymyxin’. 1950Lancet 17 June 1139/2 Polymyxin d in doses of 40 mg. per kg. for ten days produced definite injury in canine kidneys. 1956New Biol. XXI. 18 Various methods for purifying pitching yeast have been in vogue for some years... The latest approach to this problem is the suggested use of antibiotics such as polymixin. 1974M. C. Gerald Pharmacol. xxvii. 473 Polymyxin attaches to the cell membrane of bacteria, disrupting its function and causing the loss of essential intracellular materials. |