| 释义 |
ˈpenetrance
[f. L. penetrānt-em penetrant: see -ance.]
†1. The action of penetrating; penetration. Obs. rare—1.
1642H. More Song Soul i. ii. xii, Sith that this withouten penetrance Of bodies may be done.
2. Genetics. [ad. G. penetranz (O. Vogt 1926, in Zeitschr. f. ges. Neurol. und Psychiatrie CI. 809).] The extent to which a particular gene or set of genes is represented in the phenotypes of individuals possessing it, measured by the proportion of carriers having the phenotype characteristic of the gene.
1934[see expressivity b]. 1946R. R. Gates Human Genetics I. ii. 15 Lack of penetrance..has become a very important principle in human genetics... The gene is present in the germplasm, as shown by its transmission to the next generation, but for some reason it has completely failed to express itself in the soma. 1965Punch 10 Nov. 689/2 The second complication is known as penetrance. When a gene affects every individual who carries it equally it is said to have 100 per cent penetrance. 1973Nature 2 Mar. 64/2 An hereditary disease controlled by an autosomal Mendelian recessive gene with full penetrance. 1973B. J. Williams Evolution & Human Origins ii. 30/1 Environmental differences may cause one carrier of a gene to pass this threshold and show the trait whereas another carrier of the same gene does not. This is referred to as incomplete penetrance. |