| 释义 |
naloxone Pharm.|næˈlɒksəʊn|
[f. N-allylnoroxymorphone, an alternative name for the compound.]
A heterocyclic base, C19H21NO4 (or one of its salts), which resembles nalorphine in its chemical structure and antagonism to narcotics (see quot. 1968).
1964Amer. Jrnl. Med. Sci. CCXLVII. 412 The n-allyl derivative of oxymorphone (Numorphan) has recently been synthesized and found to be a potent narcotic antagonist... It has also been suggested that this preparation (Naloxone), differs from other narcotic antagonists in that its administration simultaneously with a narcotic results in antagonism of the respiratory depression but not of the analgesia induced by the narcotic. 1968Clin. Pharmacol. & Therapeutics IX. 215/1 Unlike nalorphine and cyclazocine, naloxone does not produce miosis, subjective effects, tolerance, or physical dependence. 1973Nature 23 Mar. 228/3 Binding was demonstrated by incubating tissue homogenates with tritium-labelled naloxone, a potent antagonist which precipitates withdrawal in humans addicted to opiates. |