| 释义 |
antimitotic, a. and n. Physiol.
Brit. |ˌantimʌɪˈtɒtɪk|, U.S. |ˌænˌtaɪmaɪˈtɑdɪk|, |ˌæn(t)imaɪˈtɑdɪk|, |ˌæn(t)əmaɪˈtɑdɪk|
[‹ anti- prefix1 + mitotic adj.]
A. adj. Inhibiting mitosis.
1948Jrnl. Amer. Chem. Soc. 70 2310 The importance that colchicine and its derivatives have assumed in research on the cancer problem as a result of their antimitotic properties makes it highly desirable to explore possible methods of synthesizing compounds of this type. 1961Lancet 19 Aug. 422/1 If you are in cancer research and they are offering you a new antimitotic agent, the mere mention of this would arouse your interest. 1974R. M. Kirk et al. Surgery iv. 60 A pump oxygenator can perfuse a limb or organ with antimitotic..drugs in partial isolation from the rest of the body, so that a higher concentration may be used. 2003Brit. Med. Jrnl. (Electronic ed.) 327274 Sirolimus..,a macrolide antibiotic with potent antifungal, immunosuppressive, and antimitotic properties, is produced by Streptomyces hygroscopicus, an actinomycete found in soil.
B. n. An inhibitor of mitosis, esp. an antineoplastic drug.
1948Brit. Jrnl. Pharmacol. & Chemotherapy 3 263/1 Nearly all the potent antimitotics are poisonous to normal cells at concentrations at which they exert antimitotic effects on tumour cells. 1953Science 29 May 601/2 A number of subsequent investigators have found maleic hydrazide to be an antimitotic in plants. 1976Jrnl. Pharmaceut. Sci. 65 1434/2 The development of bioassays for topical antimicrobials, antimitotics, antiperspirants, sunscreens [etc.]. 1991Acta Botanica Indica 19 186 The extent of growth inhibition was in proportion to the rise in the concentration of antimitotics. |