| 释义 |
proguanil Pharm.|prəʊˈgwɑːnɪl|
[f. propyl + biguanide + -il.]
A bitter-tasting synthetic compound, 1-p-chlorophenyl-5-iso-propylbiguanide, C11H16CIN5, which is used, in the form of its white crystalline hydrochloride, in the prevention and treatment of malaria. Cf. Paludrine.
1949Brit. Med. Jrnl. 15 Jan. 88/2 (heading) ‘Paludrine’ (proguanil) in prophylaxis and treatment of malarial infections caused by a West African strain of P. falciparum. 1956Nature 25 Feb. 368/1 Further mosquito infectivity experiments have confirmed that, in patients carrying gametocytes of a proguanil-resistant strain of P. falciparum, anopheline mosquitoes can be infected from a person taking 0·4 gm. proguanil daily. 1961New Scientist 20 Apr. 119/1 It was found that if a strain of P. gallinaceum was transmitted serially from chick to chick, and the birds were treated with gradually increasing doses of proguanil, the organisms became highly resistant to its action. 1970Passmore & Robson Compan. Med. Stud. II. xx. 20/1 Proguanil (paludrine) acts on the malaria parasite both in the blood and in the liver, probably by interfering with the reduction of folic acid. 1977Times 5 July 7/6 Protection is easy: one of the antimalarial drugs such as proguanil should be taken. |