| 释义 |
inosine, n. Biochem.|ˈɪnəʊsiːn|
Also (formerly) -in.
[a. or ad. G. Inosin (Haiser & Wenzel 1909, in Monatshefte f. Chemie XXIX. 166), f. Inosinsäure inosinic acid.]
A crystalline nucleoside, C5H9O4·C5H3N4O , in which the base is hypoxanthine and the sugar ribose, and which is used in kidney transplantation to provide a temporary supply of sugar and hence minimize ischaemic damage.
1911Jrnl. Biol. Chem. IX. 68 There is no evidence of formation of inosin in any phase of the experiment. 1916A. P. Mathews Physiol. Chem. xiv. 609 Inosine (Carnine), C10H12N4O5 . This substance is a decomposition product of inosinic acid. 1924Nature 12 Apr. 524/2 By splitting off phosphoric acid from the nucleotide, a compound of base and carbohydrate is formed, for which the term nucleoside is used—e.g. inosin and guanosin. 1933R. H. A. Plimmer Organic & Bio-chem. (ed. 5) xxxvii. 337 Inosine (from meat extracts and from adenosine) is the riboside of hypoxanthine. 1957[see ribosyl n.]. 1990Jrnl. Medicinal Chem. XXXIII. 979/2 The fluorinated inosine analogue, 4 (2′-F-dd-ara-I), corresponding to the active threo isomer 3, was synthesized chemically. |