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单词 tryparsamide
释义 tryparsamide Pharm.|trɪˈpɑːsəmaɪd|
[f. Trypanosoma + arsenic n.1 + amide.]
An arsenical organic compound, C8H10AsN2NaO4.½H2O, used to treat trypanosomiasis and syphilis of the central nervous system.
1921Jrnl. Exper. Med. XXXIII. 193 (heading) Therapeutic action of N-phenylglycineamide-p-arsonic acid (tryparsamide) upon experimental infections of Trypanosoma rhodesiense.1935Lancet 26 Jan. 193/2 After one injection of reduced tryparsamide the trypanocidal titre of the urine rapidly rose to an enormous level.1974Trypanosomiasis & Leishmaniasis (Ciba Foundation) 310 The problem of drug resistance has became of less importance since the discontinuance of tryparsamide for the treatment of established cases, and its replacement by melaminyl derivatives of arsenic such as melarsoprol and melarsonyl potassium.
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