A compound present (in the form of highly carcinogenic esters) in croton oil.
A tetracyclic alcohol; chemical formula: C20H28O6.
Various studies on the active principles of the manchineel tree have shown tigliane phorbol esters to be the likely cause of the severe reactions....
This is in striking contrast to phorbol esters, which mimic G q pathway-produced DAG and cause strongly hyperactive locomotion within 1-2 hr of omnidirectional contact.
Neutrophils stimulated to respiratory burst by phorbol myristate acetate activate IQ, and inhibitor studies have identified myeloperoxidase as the enzyme responsible.