单词	prodrug
释义	prodrug /ˈprəʊdrʌɡ / noun A biologically inactive compound which can be metabolized in the body to produce a drug.This involves gene transfer of an enzyme into tumour cells, which converts an inactive prodrug into a toxic metabolite, leading to cell death.... The influence of branching on the enzymatic stability of the compounds was investigated, as it is known that sterically hindered ester prodrugs are more stable toward enzymatic hydrolysis. Bouncing powerful X-rays off the protein crystals yielded a three-dimensional image of the dual protein structure, showing them exactly how the prodrug and the enzyme interact.
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