dimenhydrinate

di·men·hy·dri·nate

D0226700 (dī′mĕn-hī′drə-nāt′)n. A drug composed of two chemicals, diphenhydramine and 8-chlorotheophylline, used to prevent motion sickness.

[dime(thyl) + (ami)n(e) + hydrinate (hydr(am)in(e) + -ate).]

dimenhydrinate

(ˌdaɪmɛnˈhaɪdrɪˌneɪt) n (Pharmacology) a white slightly soluble bitter-tasting crystalline substance: an antihistamine used in the prevention of nausea, esp in travel sickness. Formula: C24H28ClN5O3[from dime(thyl + ami)n(e) + (diphen)hydr(am)in(e) + -ate¹]

di•men•hy•dri•nate

(ˌdaɪ mɛnˈhaɪ drəˌneɪt)

n. a synthetic antihistamine in powder form, used for treating allergic disorders and preventing motion sickness. [1945–50; dime (thyl) + (ami) n (e) + hydr(am)ine + -ate²]

Thesaurus

Noun

dimenhydrinate - antihistamine and antiemetic (trade name Dramamine) used to treat motion sicknessDramamineantiemetic, antiemetic drug - a drug that prevents or alleviates nausea and vomitingantihistamine - a medicine used to treat allergies and hypersensitive reactions and colds; works by counteracting the effects of histamine on a receptor site

Translations

dimenhydrinate

[di″men-hi´drĭ-nāt] an antihistamine used as an antinauseant, antiemetic, and antivertigo agent, especially in prevention and treatment of motion sickness, but also in other conditions in which nausea or vertigo may be a feature, administered orally, rectally, or by intramuscular or intravenous injection.

dimenhydrinate

Apo-Dimenhydrinate (CA), Arlevert (UK), Dramamine, Dramanate (CA), Gravol (CA), PMS-Dimenhydrinate (CA), Travamine (CA), TripTone

Pharmacologic class: Anticholinergic

Therapeutic class: Antiemetic, antivertigo agent

Pregnancy risk category B

Action

Prevents nausea and vomiting by inhibiting vestibular stimulation of chemoreceptor trigger zone and inhibiting stimulation of vomiting center in brain

Availability

Injection: 50 mg/ml

Tablets: 50 mg

Tablets (chewable): 50 mg

Indications and dosages

➣ Prevention and treatment of nausea, vomiting, dizziness, and vertigo

Adults and children ages 12 and older: 50 to 100 mg P.O. q 4 hours (not to exceed 400 mg/day), or 50 mg I.M. or I.V. q 4 hours p.r.n.

Children ages 6 to 12: 25 to 50 mg P.O. q 6 to 8 hours (not to exceed 150 mg/day), or 1.25 mg/kg I.M. (37.5 mg/m²) q 6 hours p.r.n.

Children ages 2 to 6: 12.5 to 25 mg P.O. q 6 to 8 hours (not to exceed 75 mg/day)

Contraindications

• Hypersensitivity to drug or tartrazine

• Alcohol intolerance

Precautions

Use cautiously in:

• angle-closure glaucoma, seizure disorders, prostatic hypertrophy

• children younger than age 2.

Administration

• For I.V. use, dilute with dextrose 5% in water or normal saline solution.

• Give each 50-mg I.V. dose over 2 minutes.

See Don't administer by I.V. route to premature or low-birth-weight infants. Solution contains benzyl alcohol, which can cause fatal "gasping" syndrome.

Adverse reactions

CNS: drowsiness, dizziness, headache, paradoxical stimulation (in children)

CV: hypotension, palpitations

EENT: blurred vision, tinnitus

GI: diarrhea, constipation, dry mouth

GU: dysuria, urinary frequency

Skin: photosensitivity

Other: decreased appetite, pain at I.M. site

Interactions

Drug-drug. Disopyramide, quinidine, tricyclic antidepressants: increased anticholinergic effects

MAO inhibitors: intensified and prolonged anticholinergic effects

Other CNS depressants (such as antihistamines, opioids, sedative-hypnotics): additive CNS depression

Ototoxic drugs (such as aminoglycosides, ethacrynic acid): masking of signs or symptoms of ototoxicity

Drug-diagnostic tests. Allergy skin tests: false-negative results

Drug-behaviors. Alcohol use: increased CNS depression

Patient monitoring

• Assess for lethargy and drowsiness.

• Monitor for dizziness, nausea, and vomiting (possible indicators of drug toxicity).

Patient teaching

• To prevent motion sickness, advise patient to take drug 30 minutes before traveling and to repeat dose before meals and at bedtime.

• Instruct patient to avoid driving and other hazardous activities until he knows how drug affects concentration and alertness.

• Caution patient to avoid alcohol and sedative-hypnotics during therapy.

• As appropriate, review all other significant adverse reactions and interactions, especially those related to the drugs, tests, and behaviors mentioned above.

dimenhydrinate

(dī′mĕn-hī′drə-nāt′)n. A drug composed of two chemicals, diphenhydramine and 8-chlorotheophylline, used to prevent motion sickness.

dimenhydrinate

di·men·hy·dri·nate

dimenhydrinate

di•men•hy•dri•nate

dimenhydrinate

dimenhydrinate

dimenhydrinate

Action

Availability

Indications and dosages

Contraindications

Precautions

Administration

Adverse reactions

Interactions

Patient monitoring

Patient teaching

dimenhydrinate

dimenhydrinate

Synonyms for dimenhydrinate

noun antihistamine and antiemetic (trade name Dramamine) used to treat motion sickness

Synonyms

Related Words