Crohn disease


re·gion·al en·ter·i·tis

a subacute chronic enteritis, of unknown cause, involving the terminal ileum and less frequently other parts of the gastrointestinal tract; characterized by patchy deep ulcers that may cause fistulae, and by narrowing and thickening of the bowel by fibrosis and lymphocytic infiltration, with noncaseating tuberculoid granulomas that also may be found in regional lymph nodes; symptoms include fever, diarrhea, cramping abdominal pain, and weight loss. Synonym(s): chronic cicatrizing enteritis, Crohn disease, distal ileitis, regional ileitis, terminal ileitis, granulomatous enteritis

re·gion·al en·ter·i·tis

(rē'jŭn-ăl en'tĕr-ī'tis) A chronic enteritis, of unknown cause, involving the terminal ileum and less frequently other parts of the gastrointestinal tract; characterized by patchy deep ulcers that may cause fistulas, and narrowing and thickening of the bowel by fibrosis and lymphocytic infiltration, with noncaseating tuberculoid granulomas that also may be found in regional lymph nodes; symptoms include fever, diarrhea, cramping abdominal pain, and weight loss.
Synonym(s): Crohn disease, distal ileitis, regional ileitis, granulomatous enteritis.

Crohn disease

, Crohn's disease (kron) [Burrill B. Crohn, U.S. gastroenterologist, 1884–1983] An inflammatory bowel disease marked by patchy areas of full-thickness inflammation anywhere in the gastrointestinal tract, from the mouth to the anus. It frequently involves the terminal ileum of the small intestine or the proximal large intestine and may be responsible for abdominal pain, diarrhea, malabsorption, formation of fistulas between the intestines and other organs, and bloody stools. Like ulcerative colitis, it is most common in the second and third decades of life. See: regional enteritis; regional ileitisinflammatory bowel disease;

Treatment

Medical therapies include anti-inflammatory drugs (such as corticosteroids), aminosalicylates (such as mesalamine), and antibodies to tumor necrosis factor. Nutritional support of the patient may be needed during flares of the disease. Surgical removal of diseased bowel segments is often followed by relapse and may result in malnutrition.

Crohn,

Burrill Bernard, U.S. gastroenterologist, 1884-1983. Crohn disease - a subacute chronic enteritis. Synonym(s): regional enteritis