DSG4


DSG4

A gene on chromosome 18q12.1 that encodes desmoglein 4, a component of intercellular desmosomes that mediates cell–cell adhesion. DSG4 co-ordinates the transition from proliferation to differentiation in hair follicle keratinocytes.
Molecular pathology
Defects in DSG4 cause hypotrichosis type 6; like desmoglein 3, desmoglein 4 is an antigen targeted in the autoimmune blistering disease pemphigus vulgaris.