| 单词 |
dsg4 |
| 释义 |
DictionarySeelahDSG4
DSG4 A gene on chromosome 18q12.1 that encodes desmoglein 4, a component of intercellular desmosomes that mediates cell–cell adhesion. DSG4 co-ordinates the transition from proliferation to differentiation in hair follicle keratinocytes.
Molecular pathology
Defects in DSG4 cause hypotrichosis type 6; like desmoglein 3, desmoglein 4 is an antigen targeted in the autoimmune blistering disease pemphigus vulgaris. |
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