| 释义 |
BRCA1 downregulation BRCA1 downregulation The reduction in BRCA1 (Breast Cancer Susceptibility Protein-1), which impedes DNA repair and commonly occurs in sporadic breast cancers. BRCA1 downregulation is associated with intraductal carcinoma, basal-like and triple-negative carcinomas and ID4 overexpression, and correlates with poor prognosis. |