| 单词 | endotoxin-binding proteins |
| 释义 | endotoxin-binding proteinsendotoxin-binding proteinsBlood proteins that bind to the dangerous endotoxin produced by GRAM NEGATIVE bacteria. Lipopolysaccharide binding protein (LBP) binds to a lipid component of bacterial endotoxin and delivers it to CD14 receptors on macrophages resulting in the release of inflammatory CYTOKINES. Another protein, the neutrophil granular protein bactericidal/ permeability-increasing protein (BPI) competes with LBP for toxin binding at the same site, blocks endotoxin delivery to macrophages and reduces the inflammatory response and the overall toxic effect. |
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