epinephrine
enUKep·i·neph·rine
also ep·i·neph·rin E0180200 (ĕp′ə-nĕf′rĭn)epinephrine
(ˌɛpɪˈnɛfrɪn; -riːn) orepinephrin
ep•i•neph•rine
or ep•i•neph•rin
(ˌɛp əˈnɛf rɪn)n.
ep·i·neph·rine
(ĕp′ə-nĕf′rĭn)epinephrine
Noun | 1. | ![]() |
单词 | epinephrine | |||
释义 | epinephrineenUKep·i·neph·rinealso ep·i·neph·rin E0180200 (ĕp′ə-nĕf′rĭn)epinephrine(ˌɛpɪˈnɛfrɪn; -riːn) orepinephrinep•i•neph•rineor ep•i•neph•rin(ˌɛp əˈnɛf rɪn)n. ep·i·neph·rine(ĕp′ə-nĕf′rĭn)epinephrine
epinephrineenUKepinephrine(ĕp'ənĕf`rīn), hormonehormone,secretory substance carried from one gland or organ of the body via the bloodstream to more or less specific tissues, where it exerts some influence upon the metabolism of the target tissue. ..... Click the link for more information. important to the body's metabolism, also known as adrenaline. Epinephrine, a catecholaminecatecholamine , any of several compounds occurring naturally in the body that serve as hormones or as neurotransmitters in the sympathetic nervous system. The catecholamines include such compounds as epinephrine, or adrenaline, norepinephrine, and dopamine. ..... Click the link for more information. , together with norepinephrinenorepinephrine , a neurotransmitter in the catecholamine family that mediates chemical communication in the sympathetic nervous system, a branch of the autonomic nervous system. ..... Click the link for more information. , is secreted principally by the medulla of the adrenal glandadrenal gland or suprarenal gland , endocrine gland (see endocrine system) about 2 in. (5.1 cm) long situated atop each kidney. The outer yellowish layer (cortex) of the adrenal gland secretes about 30 steroid hormones, the most important of which are aldosterone and ..... Click the link for more information. . Heightened secretion caused perhaps by fear or anger, will result in increased heart rate and the hydrolysis of glycogen to glucose. This reaction, often called the "fight or flight" response, prepares the body for strenuous activity. The hormone was first extracted (1901) from the adrenal glands of animals by Jokichi Takamine; it was synthesized (1904) by Friedrich Stolz. Epinephrine is used medicinally as a stimulant in cardiac arrest, as a vasoconstrictor in shock, as a bronchodilator and antispasmodic in bronchial asthma, and to lower intra-ocular pressure in the treatment of glaucoma. BibliographySee B. B. Hoffman, Adrenaline (2013). EpinephrineA hormone which is the predominant secretion from the adrenal medulla; also known as adrenalin, it has the structure shown. Epinephrine is a sympathomimetic substance; that is, it acts on tissue supplied by sympathetic nerves, and generally the effects of its action are the same as those of other nerve stimuli. Conversely, the stimulation of the splanchnic or visceral nerves will cause the rapid release of the hormone from the medullary cells of the adrenal gland. Thus, epinephrine plays an important role in preparing the organism to meet conditions of physiologic emergency. When injected intravenously, epinephrine causes an immediate and pronounced elevation in blood pressure, which is due to the coincident stimulation of the action of the heart and the constriction of peripheral blood vessels. The chief metabolic changes following the injection of epinephrine are a rise in the basal metabolic rate and an increase of blood sugar. These effects of epinephrine are transitory. See Adrenal gland, Carbohydrate metabolism ![]() epinephrine[‚ep·ə′ne·frən]epinephrineenUKepinephrine[ep″ĭ-nef´rin]Some disorders of the adrenal glands, such as addison's disease, reduce the output of epinephrine below normal. By contrast, excessive activity of those glands, as sometimes seen in highly emotional persons, tends to produce tenseness, palpitation, high blood pressure, perhaps diarrhea, and overaggressiveness. Certain adrenal tumors also result in the production of too much epinephrine. Removal of the tumor relieves symptoms. Epinephrine is also produced synthetically and can be administered parenterally, topically, or by inhalation. It acts as a vasoconstrictor, antispasmodic, and sympathomimetic, and it is used as an emergency heart stimulant as well as to relieve symptoms in allergic conditions such as urticaria (hives), asthma, and other conditions requiring bronchodilation and as a adjunct to local and regional anesthesia. It is the most effective drug for counteracting the lethal effects of anaphylactic shock. It is also used topically in the eye in the treatment of glaucoma. epinephrineepinephrine hydrochloridePharmacologic class: Sympathomimetic (direct acting) Therapeutic class: Bronchodilator, mydriatic Pregnancy risk category C ActionStimulates alpha- and beta-adrenergic receptors, causing relaxation of cardiac and bronchial smooth muscle and dilation of skeletal muscles. Also decreases aqueous humor production, increases aqueous outflow, and dilates pupils by contracting dilator muscle. AvailabilityAuto-injector for I.M. injection: 1:2,000 (0.5 mg/ml) Injection: 0.1 mg/ml, 0.5 mg/ml, 1 mg/ml Ophthalmic drops: 0.5%, 1%, 2% Solution for inhalation (as racepinephrine): 2.5% (equivalent to 1% epinephrine) Indications and dosages➣ Bronchodilation; anaphylaxis; hypersensitivity reaction Adults: 0.1 to 0.5 ml of 1:1,000 solution subcutaneously or I.M., repeated q 10 to 15 minutes p.r.n. Or 0.1 to 0.25 ml of 1:10,000 solution I.V. slowly over 5 to 10 minutes; may repeat q 5 to 15 minutes p.r.n. or follow with a continuous infusion of 1 mcg/minute, increased to 4 mcg/minute p.r.n. For emergency treatment, EpiPen delivers 0.3 mg I.M. of 1:1,000 epinephrine. Children: For emergency treatment, EpiPen Jr. delivers 0.15 mg I.M. of 1:2,000 epinephrine. ➣ Acute asthma attack Adults and children ages 4 and older: One to three deep inhalations of inhalation solution with hand-held nebulizer, repeated q 3 hours p.r.n. ➣ To restore cardiac rhythm in cardiac arrest Adults: 0.5 to 1 mg I.V., repeated q 3 to 5 minutes, if needed. If no response, may give 3 to 5 mg I.V. q 3 to 5 minutes. ➣ Chronic simple glaucoma Adults: One drop in affected eye once or twice daily. Adjust dosage to meet patient's needs. ➣ To prolong local anesthetic effects Adults and children: 1:200,000 concentration with local anesthetic Contraindications• Hypersensitivity to drug, its components, or sulfites • Angle-closure glaucoma • Cardiac dilatation, cardiac insufficiency • Cerebral arteriosclerosis, organic brain syndrome • Shock with use of general anesthetics and halogenated hydrocarbons or cyclosporine • MAO inhibitor use within past 14 days • Labor • Breastfeeding PrecautionsUse cautiously in: • hypertension, hyperthyroidism, diabetes, prostatic hypertrophy • elderly patients • pregnant patients • children. Administration• In anaphylaxis, use I.M. route, not subcutaneous route, if possible. See Inject EpiPen and EpiPen Jr. only into anterolateral aspect of thigh. Don't inject into buttocks or give I.V. See Be aware that not all epinephrine solutions can be given I.V. Check manufacturer's label. • For I.V. injection, give each 1-mg dose over at least 1 minute. For continuous infusion, use rate of 1 to 10 mcg/minute, adjusting to desired response. • Use Epi-Pen Jr. for patients weighing less than 30 kg (66 lb). See Don't give within 14 days of MAO inhibitors. ![]() Adverse reactionsCNS: nervousness, anxiety, tremor, vertigo, headache, disorientation, agitation, drowsiness, fear, dizziness, asthenia,cerebral hemorrhage, cerebrovascular accident (CVA) CV: palpitations, widened pulse pressure, hypertension, tachycardia, angina, ECG changes,ventricular fibrillation, shock GI: nausea, vomiting GU: decreased urinary output, urinary retention, dysuria Respiratory: dyspnea, pulmonary edema Skin: urticaria, pallor, diaphoresis, necrosis Other: hemorrhage at injection site InteractionsDrug-drug. Alpha-adrenergic blockers: hypotension from unopposed beta-adrenergic effects Antihistamines, thyroid hormone, tricyclic antidepressants: severe sympathomimetic effects Beta-adrenergic blockers (such as propranolol): vasodilation and reflex tachycardia Cardiac glycosides, general anesthetics: increased risk of ventricular arrhythmias Diuretics: decreased vascular response Doxapram, mazindol, methylphenidate: enhanced CNS stimulation or pressor effects Ergot alkaloids: decreased vasoconstriction Guanadrel, guanethidine: enhanced pressor effects of epinephrine Levodopa: increased risk of arrhythmias Levothyroxine: potentiation of epinephrine effects MAO inhibitors: increased risk of hypertensive crisis Drug-diagnostic tests. Glucose: transient elevation Lactic acid: elevated level (with prolonged use) Patient monitoringSee Monitor vital signs, ECG, and cardiovascular and respiratory status. Watch for ventricular fibrillation, tachycardia, arrhythmias, and signs and symptoms of shock. Ask patient about anginal pain. • Assess drug's effect on underlying problem (such as anaphylaxis or asthma attack), and repeat dose as needed. See Monitor neurologic status, particularly for decreased level of consciousness and other signs and symptoms of cerebral hemorrhage or CVA. • Monitor fluid intake and output, watching for urinary retention or decreased urinary output. • Inspect injection site for hemorrhage or skin necrosis. Patient teaching• Teach patient who uses auto-injector how to use syringe correctly, when to inject drug, and when to repeat doses. • Teach patient who uses hand-held nebulizer correct use of equipment and drug. Explain indications for both initial dose and repeat doses. See Inform patient that drug may cause serious adverse effects. Tell him which symptoms to report. • If patient will self-administer drug outside of health care setting, explain need for prompt evaluation by a health care provider to ensure that underlying disorder has been corrected. • As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs and tests mentioned above. ep·i·neph·rine(ep'i-nef'rin),See also: emergency theory, fight or flight response. epinephrinealsoepinephrin(ĕp′ə-nĕf′rĭn)adrenalineA sympathomimetic catecholamine hormone synthesised in the adrenal medulla and released into the circulation in response to hypoglycemia and sympathetic nervous system—i.e., splanchnic nerve stimulation due to exercise and stress; it acts on α- and β-receptors, resulting in vasoconstriction or vasodilation, decreased peripheral blood flow, increased heart rate, increased force of contractility, increased glycogenolysis and increased lipolysis. Pharmacologic doses of epinephrine are used as bronchodilator for acute asthma, to increase blood pressure and in acute myocardial infarctions, to improve myocardial and cerebral blood flow. Adrenaline is the official British pharmacopoeia name for epinephrine.epinephrinePhysiology A sympathomimetic catecholamine hormone synthesized in the adrenal medulla and released into the circulation in response to hypoglycemia and sympathetic nervous system–splanchnic nerve stimulation due to exercise and stress; it acts on α– and β-receptors, resulting in vasoconstriction or vasodilation, ↓ peripheral blood flow, ↑ heart rate, ↑ force of contractility, ↑ glycogenolysis, ↑ lipolysis; pharmacologic epinephrine is used as bronchodilator for acute asthma to ↑ BP and in acute MIs to improve myocardial and cerebral blood flow. See Fight-or-flight response, High-dose epinephrine.ep·i·neph·rine(ep'i-nef'rin)Synonym(s): adrenaline. epinephrineADRENALINE. Epinephrine is the favoured medical usage in the USA, but the term ‘adrenaline’ is in popular use. The drug is on the WHO official list. The terms ad and renal are Latin for ‘on’ and ‘kidney’. The corresponding terms in Greek are epi and nephron .epinephrinesee ADRENALINE.Epinephrineadrenaline (epinephrine)ep·i·neph·rine(ep'i-nef'rin)Synonym(s): adrenaline. epinephrineenUK
Synonyms for epinephrine
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