sclerostin
sclerostin
A glycoprotein secreted by osteocytes that has anti-anabolic effects on bone. It has a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists.Molecular pathology
Sclerostin is misregulated in van Buchem disease, which is characterised by increased bone mass.