peramivir
peramivir
(per-am-a-veer),Rapivab
(trade name)Classification
Therapeutic: antiviralsPharmacologic: neuraminidase inhibitors
Indications
Action
Therapeutic effects
Pharmacokinetics
Time/action profile (blood levels)
ROUTE | ONSET | PEAK | DURATION |
---|---|---|---|
IV | rapid | end of infusion | unknown |
Contraindications/Precautions
Adverse Reactions/Side Effects
Central nervous system
- insomnia
- neuropsychiatric events
Cardiovascular
- hypertension
Gastrointestinal
- constipation
Dermatologic
- skin reactions including stevens-johnson syndrome (life-threatening)
Interactions
Drug-Drug interaction
Avoid use of live attenuated influenza vaccine within 2 wk prior and 48 hr after peramivir; interference may occur.Route/Dosage
Renal Impairment
Intravenous (Adults and Children ≥18 yr) CCr 30–49 mL/min—200 mg, CCr 10–29 mL/min—100 mgAvailability
Nursing implications
Nursing assessment
- Assess for signs and symptoms of influenza (fever, dyspnea, tachypnea, tachycardia, hypotension) prior to and at least daily during therapy. Patient must be symptomatic for no more than 2 days to receive peramivir.
- Monitor for signs of neuropsychiatric symptoms (hallucinations, delirium, abnormal behavior) during therapy.
- Assess patient for skin rash during therapy. Monitor closely and treat symptomatically.
- Lab Test Considerations: May cause ↑ serum ALT, AST, glucose, creatine phosphokinase, and ↓ neutrophils.
Potential Nursing Diagnoses
Risk for infection (Indications)Implementation
Intravenous Administration
- Intermittent Infusion: Diluent: 0.9% NaCl or 0.45% NaCl, D5, or LR to a maximum volume of 100 mL. Solution is clear and colorless; do not administer solution that is discolored or contains a precipitate. Upon dilution, administer immediately or refrigerate up to 24 hrs; discard after 24 hrs. Allow to reach room temperature prior to administration.. Discard unused portion of single use vial.
- Rate: Infuse over 15 to 30 min.
- Y-Site Incompatibility: Do not administer simultaneously with any other medication.
Patient/Family Teaching
- Explain purpose of peramivir to patient.
- Advise patient to notify health care professional if signs and symptoms of anaphylaxis or rash, or neuropsychiatric symptoms occur.
- Advise female patient to notify health care professional if pregnancy is planned or suspected or if breastfeeding.
Evaluation/Desired Outcomes
- Resolution of sign and symptoms of influenza.