laminin 5
laminin 5
A complex glycoprotein composed of three subunits (alpha, beta and gamma), which is involved in:• Cell adhesion via integrin alpha-3/beta-1 in focal adhesion and integrin alpha-6/beta-4 in hemidesmosomes;
• Signal transduction via tyrosine phosphorylation of pp125-FAK and p80; and
• Keratinocytes differentiation.