Isuprel

[i´su-prel] trademark for preparations of isoproterenol, a sympathomimetic bronchodilator and cardiac stimulant.

isoproterenol hydrochloride

Isuprel

Pharmacologic class: Sympathomimetic, beta₁-adrenergic and beta₂-adrenergic agonist

Therapeutic class: Vasopressor, bronchodilator, antiasthmatic

Pregnancy risk category C

Action

Acts on beta₂-adrenergic receptors, causing relaxation of bronchial smooth muscle; acts on beta₁-adrenergic receptors in heart, causing positive inotropic and chronotropic effects and increasing cardiac output. Also lowers peripheral vascular resistance in skeletal muscle and inhibits antigen-induced histamine release.

Availability

Injection: 20 mcg/ml, 200 mcg/ml

Indications and dosages

➣ Shock

Adults and children: 0.5 to 5 mcg/minute by continuous I.V. infusion

➣ Heart block; ventricular arrhythmias

Adults: Initially, 0.02 to 0.06 mg I.V., then 0.01 to 0.2 mg I.V. or 5 mcg/minute I.V. Or initially, 0.2 mg I.M., then 0.02 to 1 mg I.M., depending on response. Or initially, 0.2 mg subcutaneously, then 0.15 to 0.2 mg subcutaneously, depending on response.

➣ Bronchospasm during anesthesia

Adults: 0.01 to 0.02 mg I.V., repeated when necessary

Contraindications

• Angina pectoris

• Angle-closure glaucoma

• Tachyarrhythmias

• Tachycardia or heart block caused by digitalis intoxication

• Ventricular arrhythmias that warrant inotropic therapy

• Labor, delivery, breastfeeding

Precautions

Use cautiously in:

• renal impairment, unstable vasomotor disorders, hypertension, coronary insufficiency, chronic obstructive pulmonary disease, diabetes mellitus, hyperthyroidism

• history of cerebrovascular accident or seizures

• elderly patients.

Administration

• Give each 0.02-mg I.V. dose by direct injection over 1 minute, or by I.V. infusion, as ordered. Always use continuous infusion pump to deliver infusion.

Adverse reactions

CNS: tremors, anxiety, insomnia, headache, dizziness, asthenia, nervousness

CV: palpitations, tachycardia, angina, rapid blood pressure changes, arrhythmias, cardiac arrest, Stokes-Adams attacks

EENT: pharyngitis, visual blurring

GI: nausea, vomiting, heartburn

Metabolic: hyperglycemia

Respiratory: bronchitis, dyspnea, increased sputum, pulmonary edema, bronchospasm

Skin: diaphoresis

Other: parotid gland swelling (with prolonged use), pallor

Interactions

Drug-drug. Cyclopropane, epinephrine, halogenated general anesthetics: increased risk of arrhythmias

Propranolol, other beta-adrenergic blockers: antagonism of bronchodilating effects

Drug-diagnostic tests. Glucose: increased level

Patient monitoring

• During I.V. administration, monitor ECG and vital signs carefully.

• Assess patient's response to drug and adjust I.V. infusion rate accordingly.

• Closely monitor arterial blood gas values, urine output, and central venous pressure.

See Stay alert for rebound bronchospasm.

Patient teaching

• Assure patient that he'll be monitored closely.

Isuprel

(ī′sə-prəl) A trademark for the drug isoproterenol hydrochloride.

Isuprel

Isuprel

Isuprel

isoproterenol hydrochloride

Action

Availability

Indications and dosages

Contraindications

Precautions

Administration

Adverse reactions

Interactions

Patient monitoring

Patient teaching

Isuprel

Isuprel

Synonyms for Isuprel

noun drug (trade name Isuprel) used to treat bronchial asthma and to stimulate the heart

Synonyms

Related Words