agranulocytosis
noun
agran·u·lo·cy·to·sis ˌā-ˌgran-yə-lō-ˌsī-ˈtō-səs 
plural agranulocytoses ˌā-ˌgran-yə-lō-ˌsī-ˈtō-ˌsēz
: an acute febrile condition marked by severe decrease in blood granulocytes and often associated with the use of certain drugs
Example Sentences
Recent Examples on the Web To prevent and rapidly address cases of agranulocytosis, the FDA requires clozapine’s manufacturers to jointly administer the clozapine REMS program. 
Brian Barnett, STAT, 9 May 2022 Someone dying from a medication side effect is devastating, but the FDA’s singular focus on agranulocytosis is myopic. Brian Barnett, STAT, 9 May 2022 The drug may cause agranulocytosis, a dangerous lowering of white blood cells that puts patients at risk of serious infections, according to Berman. Bloomberg.com, 29 Nov. 2017
Brian Barnett, STAT, 9 May 2022 Someone dying from a medication side effect is devastating, but the FDA’s singular focus on agranulocytosis is myopic. Brian Barnett, STAT, 9 May 2022 The drug may cause agranulocytosis, a dangerous lowering of white blood cells that puts patients at risk of serious infections, according to Berman. Bloomberg.com, 29 Nov. 2017 Word History
Etymology
borrowed from German Agranulozytose, from a- a- entry 2 + Granulozyt granulocyte + -ose -osis
First Known Use
1922, in the meaning defined above
Medical Definition
agranulocytosis
noun
agran·u·lo·cy·to·sis ˌā-ˌgran-yə-lō-ˌsī-ˈtō-səs
plural agranulocytoses -ˌsēz
: an acute blood disorder that is marked by a decrease of circulating granulocytes (such as neutrophils) and is characterized especially by weakness, chills, swollen neck, sore throat, mouth ulcers, and jaundice
Note: Agranulocytosis results from a decline in the production of granulocytes or from granulocyte destruction. It is typically an acquired condition occurring as a side effect of certain drugs or chemotherapy or sometimes as a complication of various medical conditions (such as infection, autoimmune disease, or aplastic anemia).
called also agranulocytic angina, granulocytopenia