Vasculogenesis occurs in the villous mesenchyme of the chorioallantoic placenta at a similarly early stage.
Graham J. Burton, Eric Jauniaux 2018, 'Development of the Human Placenta and Fetal Heart: Synergic or Independent?', Frontiers in Physiologyhttp://journal.frontiersin.org/article/10.3389/fphys.2018.00373/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The synthesized materials were implanted on the chick chorioallantoic membrane to investigate their angiogenic potential.
Abdur Raheem Aleem, Lubna Shahzadi, Farah Alvi, Ather Farooq Khan, Aqif Anwar Chaudhry,Ihtesham ur Rehman, Muhammad Yar 2017, 'Thyroxin releasing chitosan/collagen based smart hydrogels to stimulate neovascularization',Materials & Designhttp://www.sciencedirect.com/science/article/pii/S0264127517307219. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
In vivo anti-angiogenic study of the isolated compounds was also carried using chorioallantoic membrane assay.
Umar Farooq, Sadia Naz, Afshan Shams, Yasir Raza, Ayaz Ahmed, Umer Rashid, Abdul Sadiq 2019, 'Isolation of dihydrobenzofuran derivatives from ethnomedicinal species Polygonum barbatumas anticancer compounds', Biological Researchhttp://link.springer.com/article/10.1186/s40659-018-0209-0. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
In addition, it impaired angiogenesis in chick yolk sac membrane model and chorioallantoic membrane model.
Yu Yan, Xin Cheng, Ren-hao Yang, He Li, Jian-long Chen, Zheng-lai Ma, Guang Wang,Manli Chuai, Xuesong Yang 2016, 'Exposure to excess phenobarbital negatively influences the osteogenesis of chick embryos',Frontiers in Pharmacologyhttp://journal.frontiersin.org/Journal/10.3389/fphar.2016.00349/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Both compounds induced inhibition of proliferation and apoptosis in xenografts of the chicken chorioallantoic membrane.
Rainer Kuefer, Felicitas Genze, Waltraud Zugmaier, Richard E. Hautmann, Ludwig Rinnab,Juergen E. Gschwend, Marina Angelmeier, Aidee Estrada, Berthold Buechele 2007, 'Antagonistic Effects of Sodium Butyrate and N-(4-Hydroxyphenyl)-retinamide on ProstateCancer', Neoplasia: An International Journal for Oncology Researchhttp://www.sciencedirect.com/science/article/pii/S1476558607800558. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Moreover, these compounds exhibited significant antiangiogenic effects in the chick chorioallantoic membrane assay.
Narise K, Okuda K, Enomoto Y, Hirayama T, Nagasawa H 2014, 'Optimization of biguanide derivatives as selective antitumor agents blocking adaptivestress responses in the tumor microenvironment', Drug Design, Development and Therapyhttp://www.dovepress.com/optimization-of-biguanide-derivatives-as-selective-antitumor-agents-bl-peer-reviewed-article-DDDT. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Further, the anti-angiogenic effect of the compound was studied using in ovo chorioallantoicmembrane assay.
Monica Pandey, Vidya Gopalakrishnan, Hassan A Swarup, Sujeet Kumar, Radha Gudapureddy,Anjana Elizabeth Jose, Supriya V Vartak, Robin Sebastian, Mrinal Srivastava, BibhaChoudhary, Mantelingu Kempegowda, Subhas S Karki, Sathees C Raghavan 2019, 'Water-soluble version of SCR7-pyrazine inhibits DNA repair and abrogates tumor cellproliferation', Journal of Radiation and Cancer Researchhttp://www.journalrcr.org/article.asp?issn=2588-9273;year=2019;volume=10;issue=1;spage=27;epage=43;aulast=Pandey. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
There are two components to the placental membranes to consider, the secondary yolk sac and the chorioallantoic placenta.
Graham J. Burton, Eric Jauniaux 2018, 'Development of the Human Placenta and Fetal Heart: Synergic or Independent?', Frontiers in Physiologyhttp://journal.frontiersin.org/article/10.3389/fphys.2018.00373/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The virus was isolated and infection was produced on both chorioallantoic membrane and chicken embryo fibroblasts.
C. Balachandran, N. Pazhanivel, T.G. Prabhakar, V. Murugadas, P. Prabakar 2012, 'Avipox Virus Infection in Rosella parakeet (Platycercus sp.)', Journal of Advanced Veterinary Researchhttp://advetresearch.com/index.php/AVR/article/view/178. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)