Ablation here resulted in non-inducibility of ventricular tachycardia.
Dr. Raja J. Selvaraj, Pakkirisamy Gobu, Thulaseedharan S. Ashida, Geofi George, JayaramanBalachander 2012, 'Ventricular Tachycardia in Repaired Double Chambered Right Ventricle - Identificationof the Substrate and Successful Ablation', Indian Pacing and Electrophysiology Journalhttp://www.sciencedirect.com/science/article/pii/S0972629216304624. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
This versatile strategy provides reversible temporal regulation of transgenes with robust inducibility and minimal leakiness.
Aslam Abbasi Akhtar, Jessica Molina, Marina Dutra-Clarke, Gi Bum Kim, Rachelle Levy,William Schreiber-Stainthorp, Moise Danielpour, Joshua J. Breunig 2015, 'A Transposon-Mediated System for Flexible Control of Transgene Expression in Stemand Progenitor-Derived Lineages', Stem Cell Reportshttp://www.sciencedirect.com/science/article/pii/S221367111500034X. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Colony origin had no effect on inducibility or differential gene expression.
Claudia Husseneder, Dawn M. Simms 2014, 'Effects of Caste on the Expression of Genes Associated with Septic Injury and XenobioticExposure in the Formosan Subterranean Termite', PLoS ONE10.1371/journal.pone.0105582. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Patients who obtained acute procedural success with non-inducibility had better long-term outcomes (p < 0.001).
Wei Wei, Hongtao Liao, Yumei Xue, Xianhong Fang, Jun Huang, Yang Liu, Hai Deng, YuanhongLiang, Zili Liao, Fangzhou Liu, Weidong Lin, Xianzhang Zhan, Shulin Wu 2017, 'Long-Term Outcomes of Radio-Frequency Catheter Ablation on Ventricular TachycardiasDue to Arrhythmogenic Right Ventricular Cardiomyopathy: A Single Center Experience.',PLoS ONEhttp://europepmc.org/articles/PMC5266247?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Tightly regulated promoters with strong inducibility and scalability are highly desirable for biological applications.
Thomas L. Ruegg, Jose H. Pereira, Joseph C. Chen, Andy DeGiovanni, Pavel Novichkov,Vivek K. Mutalik, Giovani P. Tomaleri, Steven W. Singer, Nathan J. Hillson, BlakeA. Simmons, Paul D. Adams, Michael P. Thelen 2018, 'Jungle Express is a versatile repressor system for tight transcriptional control',Nature Communicationshttp://link.springer.com/article/10.1038/s41467-018-05857-3. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
These advances warrant further investigation of the inducibility and efficacy of such revolutionary antibody strategies in humans.
Denise A Kaminski, F. Eun-Hyung eLee 2011, 'Revolutions In Antibodies Against Influenza Virus', Frontiers in Immunologyhttp://journal.frontiersin.org/Journal/10.3389/fimmu.2011.00076/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
In the electrophysiological study, 39% of patients were inducible, but inducibilityfailed to predict subsequent arrhythmic events.
Philippon François, Geelen Peter, Champagne Jean, Brugada Pedro 2005, 'Recurrent cardiac events in patients with idiopathic ventricular fibrillation, excludingpatients with the Brugada syndrome', BMC Medicinehttp://www.biomedcentral.com/1741-7015/3/1. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Recently, the peri-infarct zones surrounding the necrotic scar (termed gray zones) have been shown to correlate with ventricular tachycardia inducibility.
Hermenegild Arevalo, Gernot Plank, Patrick Helm, Henry Halperin, Natalia Trayanova 2013, 'Tachycardia in Post-Infarction Hearts: Insights from 3D Image-Based Ventricular Models',PLoS ONE10.1371/journal.pone.0068872. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)